Anonymous
Anonymous asked in 科學生物學 · 1 decade ago

有關於apoptosis的相關paper

n-Butylidenephthalide induced apoptosis in the A549

human lung adenocarcinoma cell line by coupled

down-regulation of AP-2α and telomerase activity

這是標題

http://www.nature.com/aps/journal/vaop/ncurrent/pd... 全文 可否請大大看一下 若無法連結可以去NCBI 找看看(20點)

Update:

解釋一下 大概在說啥

1 Answer

Rating
  • 小陳
    Lv 6
    1 decade ago
    Favorite Answer

    讓戰將來回答~~

    這是在測一種抗肺癌的新葯(n-BP)的潛力, 這種葯最後結論是有效抑制肺癌細胞增長(不論生體內或生體外)!

    Aim: To investigate the role of hTERT gene expression and AP-2α in n-butylidenephthalide (n-BP)-induced apoptosis in A549 lung cancer

    cells.

    因為 (n-BP)會抑制 hTERT 基因表現使 telomerase 活性下降進而抑制肺癌細胞生長!

    而 AP-2位點是 hTERT 基因 promoter 中一段 320bp 的片段, 對於調控該基因有關鍵性影響~~

    希望以上回答有幫到您!!

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