張小弟 asked in 健康其他:保健 · 1 decade ago

非常急,拜託大家了~ 需要翻譯,別用翻譯軟體的

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The results of this study provide insight into two key areas:(1) the efficacy profile, safety profile, and potential convenienceof ferumoxytol, a novel IV iron designed to minimize immunologicalsensitivity and permit administration of large dosesas an injection; and (2) the factors that affect the hemoglobinresponse to IV iron in the current era of anemia management.

Hemodialysis patients randomized to two 510 mg injections offerumoxytol demonstrated a significantly greater increase inhemoglobin levels compared with oral iron, as well as significantlygreater increases in serum ferritin, TSAT, and CHr.

Thesuperior hemoglobin response to ferumoxytol compared withoral iron persisted after adjustment for baseline hemoglobin,TSAT, and ferritin levels. Ferumoxytol was well tolerated andwas associated with fewer adverse events than treatment withoral iron.

The therapeutic response, tolerability, and convenienceof administering a 1 g course of IV iron with just twoinjections makes ferumoxytol a potentially attractive treatmentoption for anemic HD patients.

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  • 1 decade ago
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    討論

    The results of this study provide insight into two key areas:(1) the efficacy profile, safety profile, and potential convenienceof ferumoxytol, a novel IV iron designed to minimize immunologicalsensitivity and permit administration of large dosesas an injection; and (2) the factors that affect the hemoglobinresponse to IV iron in the current era of anemia management.

    此研究結果提供了兩個當代貧血管理與控制的重點 (1)ferumoxytol的效用, 安全性, 以及潛在方便性- ferumoxytol是最新的注射型鐵劑 研發主軸為減低免疫系統的敏感性並且允許高劑量的注射 (2) 注射性鐵劑影響血紅素反應的因素

    Hemodialysis patients randomized to two 510 mg injections of ferumoxytol demonstrated a significantly greater increase inhemoglobin levels compared with oral iron, as well as significantlygreater increases in serum ferritin, TSAT, and CHr.

    洗腎病患隨機分成兩群組 一是注射兩劑510mg的ferumoxytol 另一是口服鐵劑 相較於口服組, 注射組病患的血紅素有明顯升高 同時也有較高的血清蛋白鐵, 運鐵蛋白飽和度, 和織紅血球血色素成份

    CHr = reticulocyte hemoglobin content= 織紅血球血色素成份

    The superior hemoglobin response to ferumoxytol compared with oral iron persisted after adjustment for baseline hemoglobin,TSAT, and ferritin levels. Ferumoxytol was well tolerated andwas associated with fewer adverse events than treatment with oral iron.

    將數據以各項基本值(血紅素, 運體蛋白飽和度, 血清蛋白鐵)為準稍做調整後, 相較於口服鐵劑, feruoxytol有較好的血紅素反應.

    同時Ferumoxytol對於病人有好的耐受性, 比起口服鐵劑有更少的不良藥物反應

    The therapeutic response, tolerability, and convenienceof administering a 1 g course of IV iron with just two injections makes ferumoxytol a potentially attractive treatmentoption for anemic HD patients.

    ferumoxytol 注射性1克的療程 (分兩次注射) 在藥效, 耐受度, 以及方便性 對於缺鐵性貧血病患而言將成為一個有潛力且誘人的選擇

    2009-08-19 06:44:27 補充:

    anemic HD patients = anemic Hemodialysis patient = 洗腎貧血病患

    今年6/20 FDA 已經核准 ferumoxytol 使用於慢性腎臟疾病缺鐵性貧血

    同時feruoxytol目前正被研發用於治療異常子宮出血女性的缺鐵性貧血,以及癌症及腸胃道疾病病患

    ferumoxytol也可用於血管增強核磁共振造影 以評估周邊動脈血管疾病的診斷用藥

    如果想知道更多有關ferumoxytol的資訊 請見以下連結

    http://www.amagpharma.com/products/ferumoxytol.php

    Source(s): 自己 (藥學院學生)
  • 1 decade ago

    結果顯示這個研究提供了兩個重要的部分

    這個功效數據圖表和安全性圖表還有可能合宜的靜脈鐵劑置換療法(新的靜脈內的鐵質)它是被設計去减小免疫系統的敏感性 和允許施行大劑量的注射

    做個簡單的回答!

    Source(s): 澳洲的朋友
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