promotion image of download ymail app
Promoted

懇請高手幫忙翻譯這幾段PAPER

B-Arrestin mediates desensitization and internalization of B-adrenergic receptors (beta-ARs), but also acts as a scaffold protein in extracellular signal-regulated kinase (ERK) cascade. Thus, we have examined the role of h-arrestin2 in the hAR-mediated ERK signaling pathways. Isoproterenol stimulation equally activated cytoplasmic and nuclear ERK in COS-7 cells expressing B1AR or B2AR. However, the activity of nuclear ERK was enhanced by co-expression of B-arrestin2 in B2AR—but not B1AR-expressing cells. Pertussis toxin treatment and blockade of GBr action inhibited h-arrestin2-enhanced nuclear activation of ERK, suggesting that h-arrestin2 promotes nuclear ERK localization in a GBr dependent mechanism upon receptor stimulation. B2AR containing the carboxyl terminal region of B1AR lost the B-arrestin2-promoted nuclear translocation. As the carboxyl terminal region is important for B-arrestin binding, these results demonstrate that recruitment of B-arrestin2 to carboxyl terminal region of B2AR is important for ERK localization to the nucleus.

B1- and B2-adrenergic receptors (B1AR, B2AR) are members of GPCRs co-expressing in many tissues receiving sympathetic stimulation. Although both of B1-and B2ARs stimulate the adenylyl cyclase-protein kinase A pathway via Gs, many differences in functional properties between B1AR and B2AR have been reported. For instance,B2AR can activate cell survival signals, whereas B1AR elicit apoptotic pathways in cardiomyocytes.

哪位高手幫忙翻譯~感激不盡 贈送二十點

不要用翻譯機

1 Answer

Rating
  • Anonymous
    1 decade ago
    Favorite Answer

    B Arrestin 介導脫敏和國際化的 B 腎上腺素能受體 (測試版-出入),也充當一支架蛋白細胞外信號調節激酶 (ERK) 級聯。 因此,我們已研究 h arrestin2 信號通路的哈爾介導 ERK 中的作用。 異丙腎上腺素刺激同樣啟動胞漿和表示 B1AR 或 B2AR COS-7 細胞中的核 ERK。 但是,活性的核 ERK 增強的 B arrestin2 中 B2AR 共表達 — 但不是 B1AR 表達細胞。 百日咳毒素治療和抑制 GBR 行動的封鎖 h arrestin2 增強核啟動的建議,h arrestin2 的外信號調節激酶促進對受體的 GBR 依賴機制中的核 ERK 定位刺激。 B2AR 含 B1AR 羧終端區失去,促進 B arrestin2 核移位。 由於羧終端地區是重要的 B arrestin 綁定,這些結果顯示該的招聘 B arrestin2 B2AR 羧終端區是重要的 ERK 向核的當地語系化。

    B1 及 B2 腎上腺素受體 B2AR B1AR) 是 GPCRs co-expressing 的成員在許多組織接收交感神經刺激。 雖然這兩 B1-和 B2ARs 刺激 adenylyl 環化酶蛋白激酶 gs,通過一途徑很多已報告 B1AR 和 B2AR 之間的功能特性差異。例如 B2AR 可以而 B1AR 引出啟動細胞生存信號,在心肌細胞凋亡通路.

    Source(s):
    • Commenter avatarLogin to reply the answers
Still have questions? Get your answers by asking now.