Most worksheets are usually storing things like people's Names, Addresses, Phone Numbers, etc...
Such information is better stored in an MS-Access database. You would create a Primary Table that held all of the information that defines the people (name, birthdate, gender, race, etc...). Another Table would hold the physical Addresses, and yet another table for the Phone Numbers. These additional tables are secondary to the initial table, and are joined by a One-To-Many relationship (allowing any one person to have multiple entries in the other tables).
And it is best to save the MS-Excel Worksheet as a .CVS file before importing that into MS-Access. This is because Microsoft tries to do things with the data, thinking it knows what is best for you. By using a .CVS file as an in-between step, you can better control the importing of the data.