Wold you Expect the Initial Production of H1N1 Vaccine to Be Low?
It is Advisable Not to Waste it:
Thanks .*., I Often Wondered Why the N Antigen wasn't Used in Vaccines, Currently, Only H Antigens Are Used In Parental Vaccines.
.*., Sorry, "Parenteral".
FLUVIRIN® is a trivalent, sub-unit (purified surface antigen) influenza virus
vaccine prepared from virus propagated in the allantoic cavity of embryonated hens’ eggs
inoculated with a specific type of influenza virus suspension containing neomycin and
polymyxin. Each of the influenza virus strains is harvested and clarified separately by
centrifugation and filtration prior to inactivation with betapropiolactone. The inactivated
virus is concentrated and purified by zonal centrifugation. The surface antigens,
hemagglutinin and neuraminidase, are obtained from the influenza virus particle by
further centrifugation in the presence of nonylphenol ethoxylate, a process which
removes most of the internal proteins. The nonylphenol ethoxylate is removed from the
surface antigen preparation.
FLUVIRIN® is a homogenized, sterile, slightly opalescent suspension in a
phosphate buffered saline. FLUVIRIN® has
FLUVIRIN® has been standardized according to USPHS
requirements for the 2008-2009 influenza season and is formulated to contain 45 mcg
Novartis Vaccines and Diagnostics Limited BLA 1750
hemagglutinin (HA) per 0.5-mL dose in the recommended ratio of 15 mcg HA of each of
the following 3 strains: A/Brisbane/59/2007(H1N1); A/Uruguay/716/2007 (H3N2), an
A/Brisbane/10/2007-like strain; and B/Florida/4/2006.
Note: After Initial Purification, the H and Ns Show Up, but Only the HAs Are In the Final Product. I Heard they Are Separated By Some "Easy" Chromotography(Sp?).
- Anonymous1 decade agoFavorite Answer
yes the year production would be max 600 million does provided we stop making other flu vaccines, Two shots will be needed so three hundred million people from 6 billion will immuniased, however as it is H1 and not H2 H3 or H4 older people will already have immunity
- .*.Lv 61 decade ago
Frankly when the N1 component mutates, and I suspect it will, any specific vaccine for the H1N1 will be a waste of time and money.
What has spread out of Mexico in as a second and third generation infection of the H1N1 has already shown signs of weakening as it gets into populations that have already seen the H1 component in previous waves fo flu.
I have not had a flu shot since 1975. Each year I get a little cold like reaction to the flu, and yes I know for a fact I have had the flu at least 8 times since 197 because my doctors have been amazed that I have not gotten sicker than I have. OH Well!!
I plan to allow nature to resolve the issues with the flu and create natural immunities to the virus' as they come along.
Frankly, I think I am better for it.