There are a of different factors that would disclude people from being able to donate, one is age, two is genetics and three is the following diseases:
HIV, Aids – the viruses in both of these ailments live deep within the tissues for a very long time, and often medications are needed in order for there to be any relief from it. In the fact of donor relations, they would have to carefully screen for this, as the people who need to have these body parts often already have an impaired immune system, and this would impair it even further.
Hemophilia – this is a blood disorder in which the clotting factor is not there, and that might pose a danger for a new item in order to be donated to someone else, as this might work at thinning that person’s blood, or there may be other situations that arise such as aneurysms (bulging of the blood vessels), or other related blood problems.
Diabetes – this is particularly important if you’re putting something like the pancreas or those type of organs into someone else since it might make that other person a diabetic as well since there are blood sugar issues, and other sorts of factors that may make an individual become resistant to insulin, or other metabolic issues.
Cancer – they have to really carefully screen for this ailment quite closely as if they put an organ out of someone who has had cancer, then the problem can replicate in the new donor’s body as there are fresh cells that these cancerous cells can latch on and become cancerous as well. You also have to worry about metastasis (spreading) as well. A couple of types of cancer that are particularly important are leukemia, smooth muscle cancer, non hodgkins lymphoma.
Heart Disease – this is particularly important as well, since it affects the blood and it effects the different processes within the body, and there is a possibility that the donated organ will be rejected if the immune system in the recipient’s body starts attacking it.
Anemia – this is a condition in which there is an excessive loss of oxygen as a result of a loss of red blood cells. If you get an individual’s donated organ from an individual that has had this problem, then the chances of another problem would be immediate, and that would prove worthless.
Cirrhosis of the Liver – this is also a particularly important part if the donated part to a person is the portion of the liver. If it has been from a damaged person, then the implications could be bad for the recipient as the liver in their bodies could become damaged as well, and that is not what the purpose of donations are for.
Gynecological Problems – I know that this might seem weird that I am including this portion within this section, but there are conditions in which the female system can create such as endometriosis (which can spread to other organs within the body such as the stomach and other parts of the body), ovarian cysts and uterine fibroids that can push on the various digestive organs.
Multiple Sclerosis also known as (MS) – this is a neurological problem, but because of the demyelination of the sheath that surrounds the neurons and nerves, it might make it an incompatible match as well, since it may have some bearing on whether it will do the same to the recipients body.
Other Autoimmune Diseases such as Amytrophic Lateral Sclerosis (ALS), Lupus, Fibromyalgia, Hyper/hypothyroidism, etc. are other conditions in which have to be carefully looked for as well in the donated organ, as these can affect the individual as well. With some of these issues, the body of the affected person, the cells could have started to attack themselves and even the own body’s cells, so donated organs with these conditions might not be a viable option.
It is really important that they cross match different things as this is really important for a successful donation. Please note that these are just some of the more common types of ailments out there that they may have to screen for. There are other ailments too such as malaria, typhoid fever, and other things like that as well that they have to cross match for.