Prescription drug interactions?

I take Effexor XR and was prescribed Imitrex for migraines. I would like to know the best site to look for information about possible interactions between the 2 medications.

1 Answer

  • 1 decade ago
    Favorite Answer

    Google is a good place to start.

    The search:


    Selective Serotonin Reuptake Inhibitors/Serotonin Norepinephrine Reuptake Inhibitors and Serotonin Syndrome

    Cases of life-threatening serotonin syndrome have been reported during combined use of SSRIs or SNRIs and triptans (see WARNINGS).

    Date: Thu, 12 Feb 1998 07:52:46 -0800

    From: Stephen Nagy <>

    Subject: Sumatriptan with SSRIs

    I am concerned about the potential interaction between sumatriptan (5-HT-1 agonist) and the SSRIs. In particular, I have a patient on sertraline 250 mg...

    --Holly A. Swartz, M.D.

    I have several patients who take both SSRIs and sumatriptan, and despite the theoretical concern about precipitating a serotonin syndrome, I have not seen anything like that occur. None of them are on a comparable dose, however.

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