Anonymous
Anonymous asked in Science & MathematicsBiology · 1 decade ago

Link between MTHFR and leukemia ?

Please explain.

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  • Anonymous
    1 decade ago
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    The enzyme 5, 10-methylenetetrahydrofolate reductase (MTHFR) is responsible for catalyzing the reduction of 5, 10-methylenetetrahydrofolate to 5-methylenetetrahydrofolate, the predominate circulatory form of folate and a carbon donor for the remethylation of homocystine to methonine. Mutations (C677T, A1298C) in the MTHFR gene have been reported to be associated with elevated levels of plasma homocysteine1, an independent risk factor for both venous and arteriosclerotic vascular disease. This elevated plasma homocysteine may be mild in MTHFR heterozygotes (C677T) or pronounced in MTHFR homozygotes (C677T/C677T). MTHFR C677T homozygosity has been shown, in some studies, to be associated with early-onset arteriosclerotic vascular disease, thrombosis, pre-eclampsia (in pregnant females), neural tube defects (in fetus carried by homozygous mothers), and hyperhomocysteinemia(1). The C677T mutation is very common in the general population and approaches 45% in Caucasians. The risk for vascular disease may be further elevated in patients who also carry the MTHFR A1298C mutation(2). As such, reflex testing for the A1298C mutation is recommended for anyone who is heterozygous or homozygous for the C677T mutation. MTHFR mutation has also been shown to be associated with thrombotic episodes and predisposition to acute lymphoblastic leukemia(3,4).

    References in link.

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  • Anonymous
    6 years ago

    iv,e dealt with this diagnosis and am more confused as ever as what happens to my body.

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