Anonymous
Anonymous asked in 科學動物學 · 1 decade ago

UVA irradiation的paper 可以幫我找嗎?!

UVA IRRADIATION OF MELANOMA CELLS MIGHT ENHANCE THEIR METASTATIC POTENTIAL

有沒有人可以幫我找到這一篇的全文

他是在2000年ASP annual meeting發表的

我只有找到abstract

可不可以幫我找找看有沒有全文

謝謝你們!!

2 Answers

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  • 阿飛
    Lv 5
    1 decade ago
    Favorite Answer

    此篇也許可再供參考

    1: Photodermatol Photoimmunol Photomed. 2005 Aug;21(4):183-90. Links

    Ultraviolet A exposure might increase metastasis of mouse melanoma: a pilot study.Pastila R, Leszczynski D.

    Department of Research and Environmental Surveillance, STUK-Radiation and Nuclear Safety Authority, Helsinki, Finland. riikka.pastila@stuk.fi

    BACKGROUND: The major sources of long-wave ultraviolet A radiation (UVA; 320-400 nm) exposure are extensive sunbathing and tanning in solaria. While the carcinogenic effects of mid-wave ultraviolet B radiation (UVB; 280-320 nm) are well recognized, the potentially hazardous effects of UVA are less understood. Several studies have shown that a variety of physiological processes in the cell are modified by UVA exposure, some of which might be involved in the regulation of tumor metastasis. In this study we suggest that UVA radiation could lead to the increase of metastatic capability of melanoma cells in mice. METHOD/RESULT: A pilot in vivo study was executed using C57BL/6 mice and syngeneic B16 melanoma cell lines. Mice were intravenously (i.v.) injected with either B16-F1 or B16-F10 melanoma cells into the tail vein and then immediately exposed to UVA. Fourteen days after melanoma injection, lungs were collected and the quantity and quality of metastases were determined under a dissecting microscope. As an outcome of the pilot study we observed that i.v. injected melanoma cells formed more lung metastases in the UVA-exposed mice in comparison with the control mice. CONCLUSION: This result suggests that the UVA exposure of mice, with melanoma cells present in blood circulation, increases the formation of melanoma metastases in lungs. Further studies should determine whether a similar pro-metastatic effect, as observed in mice, could occur in humans and whether other than melanoma tumors might be susceptible.

    PMID: 15998366 [PubMed - indexed for MEDLINE]

    Source(s): PubMed
  • 1 decade ago

    我有全文

    請先寄信給我吧

    jordans100@yahoo.com.tw

    Source(s): database
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