Which is the better cytotoxic drug,adriamycin or ifosfamide for synovial sarcoma. i have been advised to take ?

adriamycin or ifosfamide, which is better for synovial sarcoma in a lady of 65yrs. primary on the thigh and has a couple of small pulmonary nodes which are not resectable.

2 Answers

  • 1 decade ago
    Favorite Answer

    SYNOVIAL SARCOMA is a rare soft-tissue sarcoma defined by the presence of a unique translocation, t(X;18)(q11.2;p11.2). It usually occurs adjacent to joints in the limbs and was originally thought to arise from synovium. The synocial sarcomas are cancerous (malignant) tumors that originate in the soft tissues of your body. Soft tissues connect, support and surround other body structures. The soft tissues include muscle, fat, blood vessels, nerves, tendons and the lining of your joints (synovial tissues). A large variety of soft tissue sarcomas can occur in these areas.

    Chemotherapy medicine for Synovial Sarcoma -

    Conventional chemotherapy, (for example, Doxorubicin hydrochloride and Ifosfamide), is given to reduce the number of remaining microscopic cancer cells. The benefit of chemotherapy in synovial sarcoma to overall survival remains unclear, although a recent study has shown that survival of patients with advanced, poorly differentiated disease marginally improves with doxorubicin/ifosfamide treatment.

    Doxorubicin, which kills cancer cells, is among the most widely used chemotherapy drugs. It is also known by its trade name, Adriamycin.

    Since doxorubicin is used to treat so many different cancers, a complete description of how it may be combined with other medications in the treatment of each of the cancers cannot be given here.

    Ifosfamide chemically interferes with the synthesis of the genetic material (DNA and RNA) of cancer cells by cross-linking of DNA strands, which prevents these cells from being able to reproduce and continue the growth of the cancer. Ifosfamide is approved by the Food and Drug Administration (FDA) to treat germ cell cancers. It is generally prescribed in combination with another medicine (mesna).

    In the case of Synovial Sarcoma both Doxorubicin hydrochloride and Ifosfamide have the same effect and any of these drugs can be administrated and the Medical oncologist is the best person to select the drug depending on the findings by him, about the disease.

    You can take any of them as advised by the Oncologist. -

    Source(s): -
  • Panda
    Lv 7
    1 decade ago

    You should ask this question from others who have synovial sarcoma . . they've been through this before and can help.

    The ACOR email support group has an active Sarcoma list and there are people who post there who have Synovial Sarcoma. That would be a good place to start:

    SARCOMA: The General Sarcoma (Cancer) Online Support Group


    You might also post on the message board at the Sarcoma Alliance . . there are folks with synovial sarcoma who visit there too.

    Synovial sarcoma is a rare soft tissue cancer. It is always best to be treated by a sarcoma specialist or a sarcoma center if possible. You can find a list of these facilities at the Sarcoma Alliance.

    As for your original question . . my son had a rare aggressive sarcoma and took Vincristine, Adriamycin, Cytoxin cycled with Ifosfamide and Etoposide. I am not certain why the lady is just being offered one chemo drug as they work better in combination. Of the two you mention though . . I have always thought that Adriamycin (Doxirubicin) was the most toxic and probably the most effective in shrinking my sons tumors. He was no evidence of disease for eight months after taking the above treatment protocol. He eventually relapsed as sarcoma can be difficult to control.

    Good luck.

    Source(s): Experience. Lost teenage son to abdominal sarcoma.
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