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Anonymous asked in Science & MathematicsChemistry · 1 decade ago

Comparing Chromium 3+ and Chromium 6+, which one is more toxic?

3 Answers

  • Dan S
    Lv 7
    1 decade ago
    Favorite Answer

    Chromium 6+ is toxic

    Chromium 3+ is considered to be not toxic and is needed for life.

    (huge doses could be toxic though, but not in dosages of up to 4,000 times of the toxic levels of Chromium 6+. Higher doses could cause cancer, but that has only been proven in rats.)

    - Chromium 6+ can be toxic in as small concentrations as 0.05 milligrams per liter.

    - The lethal dose of poisonous chromium 6+ compounds is about one half teaspoon of material.

    Of course in large enough quantities Chromium 3+, like anything can be toxic. But it is required for sugar metabolism in humans, and a deficiency of Chromium 3+ causes a disease called chromium deficiency.

    μg = a microgram is 1/1,000,000 of a gram (1 × 10^-6)

    μg = 1/1000 of a milligram = 0.001 milligrams (1X10^-3).

    According to the WHO (World Health Organization) recommended values of daily chromium should be 25-35 micrograms, however supplements as high as 200 micrograms have been sold without any reported problems. In rats such dosages can cause chromosome damage, but that is the dietary supplement chromium picolinate.

    Smaller amounts of Chromium 3+ are recommend for health between 500 and 700 times the lethal dosage of Chromium 6+, but it is possible to take large (unknown, but over 4,000 times the lethal level of Chromium 6+) levels of Chromium 3+ without receiving more than some chromosome damage; this kind of damage CAN lead to cancer.

    According to Wikipedia:

    "Trivalent chromium (Cr(III), or Cr3+) is required in trace amounts for sugar metabolism in humans (Glucose Tolerance Factor) and its deficiency may cause a disease called chromium deficiency. In contrast, hexavalent chromium is very toxic and mutagenic when inhaled as publicized by the film Erin Brockovich. Cr(VI) has not been established as a carcinogen when not inhaled but in solution it is well established as a cause of allergic contact dermatitis (ACD).

    Recently it was shown that the popular dietary supplement chromium picolinate complex generates chromosome damage in hamster cells. In the United States the dietary guidelines for daily chromium uptake were lowered from 50-200 µg for an adult to 35 µg (adult male) and to 25 µg (adult female)...

    Chromium metal and chromium(III) compounds are not usually considered health hazards; chromium is an essential trace mineral. However, hexavalent chromium (chromium VI) compounds can be toxic if ingested or inhaled. The lethal dose of poisonous chromium (VI) compounds is about one half teaspoon of material. Most chromium (VI) compounds are irritating to eyes, skin and mucous membranes. Chronic exposure to chromium (VI) compounds can cause permanent eye injury, unless properly treated. Chromium(VI) is an established human carcinogen. An investigation into hexavalent chromium release into drinking water formed the plot of the motion picture Erin Brockovich.

    World Health Organization recommended maximum allowable concentration in drinking water for chromium (VI) is 0.05 milligrams per liter. Hexavalent chromium is also one of the substances whose use is restricted by the European Restriction of Hazardous Substances Directive.

    In some parts of Russia, pentavalent chromium was reported as one of the factors of incidence of premature senility."

    Source(s): chromium deficiency:
  • Anonymous
    5 years ago

    The oxidation. Chromium 3 has a +3 charge; chromium 6 has a +6 charge

  • Anonymous
    6 years ago


    Comparing Chromium 3+ and Chromium 6+, which one is more toxic?

    Source(s): comparing chromium 3 chromium 6 toxic:
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