How do I free disk space on my hard drive permanently without compressing files?

I only have 400 mb left on my hard drive, I've deleted programs and compressed files and have run disk clean up daily, I've used a registry cleaner and moved program files to my "E" drive which has plenty of space, I tried using disk defragmenter but it won't allow me to do this as I only have 8% free disk space. ... show more I only have 400 mb left on my hard drive, I've deleted programs and compressed files and have run disk clean up daily, I've used a registry cleaner and moved program files to my "E" drive which has plenty of space, I tried using disk defragmenter but it won't allow me to do this as I only have 8% free disk space. Is there a way to free disk space to permanently delete old compressed files that are not needed? What should I do to gain disk space, my computer runs so slow.
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