Alice's early history is very vague, as she remembers nothing of her human life. It is later revealed that she was born around 1901 in Biloxi, Mississippi and was kept in an asylum because she had premonitions, which intensified into her "special ability" when she was changed into a vampire. Alice was changed by a vampire who worked at the asylum in order to protect her from James, a tracker vampire who was hunting her. She and Bella are the only two people who have ever escaped James. After doing some research, Alice discovered that she had a sister named Cynthia, and that Cynthia's daughter, Alice's niece, is still alive in Biloxi. Alice foresaw Jasper finding her in a vision before he even knew he was looking for her. They met face-to-face in a diner located in Philadelphia, where she told him that she had been waiting a long time for his arrival. A little bewildered but intrigued with her knowing him, Jasper "ducked his head like a good southern gentleman" and answered, "I'm sorry, ma'am." She offered him her hand, a non-verbal question of whether or not he would like to go with her. He did indeed take her hand, as the sight of it brought him hope "for the first time in almost a century". During their companionship and travels, they fell in love. By 1950, they found Carlisle with more assistance from her visions and have been part of his coven ever since.
Alice and Jasper have been together since the 1950s, but are not as flamboyant about their relationship as Rosalie and Emmett are. They are stated to be soul mates and have been married legally. Their distinctly understanding love is what separates them from other couples, and they are both very protective of each other.