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- YCPLv 51 decade agoFavorite Answer
refers to degenerative changes in cells (especially in tissue culture) associated with the multiplication of certain viruses. When in tissue culture, the spread of virus is restricted by an overlay of agar (or other suitable substance) and thus the cytopathic effect may lead to formation of plaque. Thus identification of a viral infection can be made by examining the characteristic cytopathic effect produced on different cell sheets. This method however is relatively slow and not all viruses will grow on cell sheets.
Cytotoxicity is the quality of being toxic to cells. Examples of toxic agents are a chemical substance or an immune cell.
Cytotoxicity can be measured by the MTT assay, Trypan blue (TB) assay, Sulforhodamine B (SRB) assay, WST assay and clonogenic assay.
Antibody-dependent cell-mediated cytotoxicity (ADCC) describes the cell-killing ability of certain lymphocytes, which requires the target cell being marked by an antibody. Lymphocyte-mediated cytotoxicity, on the other hand, does not have to be mediated by antibodies; nor does complement-dependent cytotoxicity (CDC), which is mediated by the complement system.
Three groups of cytotoxic lymphocytes are distinguished:
Cytotoxic T cells
Natural Killer cells
Natural Killer T cellsSource(s): 維基
- Anonymous1 decade ago