How do you trim the nails of a 150 lb Mastiff who hates it.?

She will nip, struggle and make it impossible to trim her nails, plus she weighs 150 lbs which only makes it harder.
Update: I tried to take her to the groomers but she nipped at the groomer so they refused to do it, and the vet wants 110 dollars because they want to sedate her. I cant pay 110 every time the nails need to be done. any advice on doing it myself?
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