I don't know about "Vaude Karakorum", but I have owned the Cannondale front and rear panniers for the last 18 years, and overall I've been satisfied with them. They are more expensive, and if you use them a lot, they will have to have to be patched and have worn out zippers replaced.
I hardly ever use the front panniers except when I tour. I like the fact that the Cannondale bags have a frame and open from the side, so they can support camping gear or pizzas on top with bungee chords. A lot of bags have no frame, so you would have to pack them just so they can support a load on top of the rack. Top loading bags would be better for carrying long items that extent out of the bag, but the Cannondales can still do it by closing the zipper from both sides to secure the item poking out the top.
They come on and off easily -- maybe too easily. I wish there was a way to lock the bags to the frame or rack so that I could lock the zippers together with small travel locks and not have to take them off all the time to avoid theft. 4 panniers can be hard to carry with your hands. Maybe, they should be designed to carry on your back somehow?
I used to use my rear Cannondale bags every day, but now I am in the habit of buying $5 shoulder bags at thrift stores. They are cheap, easier to carry, and are better for carrying things like glass jars and long items that extend out of the bag.
Keep in mind that if you plan on touring like I have, 4 pannier bags may not be able to carry all your camping gear, food, tools, clothing, etc, and the bike may not be able to take the weight. In such a case, you would need a trailer or a 2nd person to help carry heavy tools and camping gear. You should have a 2nd person to split the cost of hotel rooms and for safety anyways.
If you plan on just using hotels and restaurants when you tour, then 4 panniers should do the job; however, on my last tour, I wished I had had a tent because it can be hard when you have to make it to the next town to get a room when it's late and dark. Hotels tend to pressure you out of the room by 11:00 A.M. anyways, so why pay for 1/2 of a nights sleep.
I also bought the Cannondale handlebar bag and the Cannondale seat bag, but I took them back because they were so small that they were not worth it. Of course they would work if we didn't have to worry about theft. I have lost 1 bear bell and 2 computers (I don't know why they steal these without a mount???), proving that anything not locked or fastened gets stolen.