Down Syndrome Question. 10 points to best answer!?
If a female with down syndrome has a baby, will the child also have down syndrome and/or what would the effects be?
- Anonymous1 decade agoFavorite Answer
Down syndrome is a chromosome anomaly. It has next to nothing to do with genes.
In over 94% of cases it is a random act of simply having 3 - 21st chromosomes instead of the typical 2. This happens during conception. There is no evidence that this has any genetic cause. (This is why it is also called Trisomy 21 - tri means 3, somy relates to a chromosome.)
In less than 3% it is from one chromosome not dividing during conception properly - there is no known genetic component to this form either. The mother's age was once considered a high risk factor, but this thinking is changing. This form is called mosaic Down syndrome and often times a person will not know they even have this. People with this form often have considerably less, if any cognitive disability. I know a person who found out they had it when they had a chromosome test done because their family had a history of an inheritable genetic disability.
The third form which also happens in about 3% of cases is from translocation. A part of the 14th chromosome breaks off and translocates into a 21st chromosome. This form is inheritable. This form is also easily identifiable by a chromosome test that most babies with Down syndrome will have had to confirm that they have it.
There are 117 possible characteristics to Down syndrome. They vary from cognitive disability, skeletal abnormalities, epilepsy, far sightedness, holes in their heart valves, hearing impairments, and obviously more. Some people have very severe forms of some characteristics, while others do not have the characteristic at all.
The life expectancy of a healthy person with Down syndrome is the same as a person without. If a person with Ds has a heart condition or epilepsy - obviously their life expectancy can be much shorter.
Males with Down syndrome have been found to generally be sterile - females are not. Unless a woman has the translocation form of Down syndrome she is at no increased risk of having a child with Down syndrome.Source(s): Adoptive parent of a 24 year old with Down syndrome whose mother was 16 when he was conceived. She had 7 children that I know of and none of the others had Ds.
- 1 decade ago
The vast majority of cases of Down syndrome are not inherited. Only in cases of Translocation Down syndrome and then in only 1 of 3 cases of this type of Down syndrome is the condition inherited. These inherited cases occur because one of the parents is a carrier. A carrier will have 45 chromosomes instead of 46 but they will have all the genetic material of a person with 46 chromosomes. Remember that in Translocation Down syndrome the extra chromosome 21 material is located on a different chromosome. A carrier will have the extra material but will have only one chromosome 21. The carrier will not exhibit any of the symptoms of Down syndrome because they have the correct amount of genetic material.
A carrier will have an increased chance of having a child with Down syndrome. If the carrier is the mother, the chances are approximately one in five of having a child with Translocation Down syndrome. If the carrier is the father the odds are reduced to between one in twenty to fifty. In cases where the carrier has no unattached chromosome 21, all the carriers children will have Down syndrome. In all cases of Down syndrome but especially in cases of Translocation Down syndrome, it is important that the parents have genetic counseling to determine their risk.
Men with Down syndrome can father a child, the first fully documented case in literature being in 198914, the second reported in 1994 in Germany16, and the third, a 26-year-old man with confirmed nonmosaic trisomy 21, fathering a "normal" son17.
A woman with Down syndrome conceiving with a "normal" male has a 10% theoretical chance (the reported rate is 48%) of having a child with Down syndrome, since half of the woman's eggs would have an extra chromosome, but approximately 80% of pregnancies where the fetus has Down syndrome would be expected to end in spontaneous miscarriage. Bovicelli et al. (1982) comprehensively reviewed reports of 30 pregnancies in 26 women with Down syndrome between 1917 and 1982. The outcome of the pregnancies was 10 babies with Down syndrome, 17 "normal" (6 had mental or physical retardation or nonspecific congenital malformations) and 3 abortions or stillbirths. In the 15 cases of known or supposed paternity, 8 fathers were mentally retarded and the remaining 7 were close relatives of the women with Down syndrome. There is an additional case from Finland, not reviewed by Bovicelli, of a "normal" son born to a mother with Down syndrome and a 63-year-old father (
- SonshineLv 41 decade ago
If a female with Down's Syndrome has a child - there is a 50 percent chance the child will be affected. This is if the father doesn't have Down's as well.
If both parents have Down's Syndrome it is very likely that the child will have Down's Syndrome.
The mother is usually the carrier of the gene affected.
- BP_Puff&StuffLv 41 decade ago
It is not 100% but it is more likely.
The effects of person with Downs having a child are no different than the effect of anyone else having a child. Downs ranges in severity so it could be that she would raise her child with minor assistance from others or, she will adopt the child out.Source(s): Worked with the disabled. Cousin with Downs
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- 1 decade ago
Not necessarily. There have been cases (at least one that I know of) in which both parents had Downs and the child did not. With that said, the odds are not good for an unaffected baby. It's all about genetics.
- 1 decade ago
fist of all when you have downs syndrome you have down syndrome they are all 100% downs if you have 3 copys of t21 then every little bit of you has down syndrome
Significantly impaired fertility of both sexes is evident in the Down syndrome population (Rogers and Coleman, 1992). While males have long been assumed to be sterile, Sheridan reports one case of a cytogenetically normal male infant that was fathered by a man with Down syndrome (Sheridan et al, 1980). Women have impaired but still significant fertility: a number of reviews document women with Down syndrome carrying pregnancy to term and delivering infants with and without Down syndrome (Bovicelli et al, 1982; Rani et al, 1990). Infants born to mothers with Down syndrome are at increased risk for premature delivery and low birth weight (Bovicelli et al, 1982). Pregnancy outcomes obtained from a study of mothers with Down syndrome are displayed in Table 5. Whether a woman with Down syndrome constitutes a high risk pregnancy depends largely on cognitive level and medical status. Obviously, the presence of maternal cardiac, thyroid, or hepatic disease, as well as seizure disorder, complicates a pregnancy. The high incidence of congenital heart disease in any offspring with Down syndrome contributes to pregnancy risk, including stillbirth and neonatal death (Gordon, 1990). Offspring without Down syndrome have a greater than average number of congenital anomalies (Bovicelli et al 1982) (see Table 5).
Table 5. Reported results of pregnancy in Down syndrome
Paper Parent Offspring
Sheridan et al, 1989 1 man with Down syndrome 1 normal male
Bovicelli et al, 1982 26 women with Down syndrome 10 normal
10 Down syndrome
2 mentally retarded
1 set of premature, nonviable normal twins
1 slightly microcephaly
1 still born
2 abortion, phenotype unknown
Rani et al, 1990 1 woman with Down syndrome 1 normal
32 pregnancies total
Ref: Sheridan et al, 1989; Bovicelli et al, 1982; Rani et al, 1990.
1 month agoSource(s): hope this helps
- Anonymous1 decade ago
it has nothing to do with how severe/mild the down syndrome is-
is is genetic-caused by a mutation-the mutation can than be passed down ........
- 1 decade ago
It depends on how severe the woman has down syndrome..and it all depends if the father has it too