美國國家科學院期刊1999年7月的原文發表

1999年7月權威的美國國家科學院期刊"Proceeding of the National Academy of Science"科學性文章提出兒茶素有預防及減緩類風濕性關節炎作用~我想找此期刊的英文原文~

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  • 1 decade ago
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    1999年7月的美國國家科學院期刊無類似文章,但在同年4月13日的Vol. 96, Issue 8, 4524-4529, April 13, 1999,有一篇 "Prevention of collagen-induced arthritis in mice by a polyphenolic fraction from green tea", 是比較相關的論文。摘要如下:

    Identification of common dietary substances capable of affording protection or modulating the onset and severity of arthritis may have important human health implications. An antioxidant-rich polyphenolic fraction isolated from green tea (green tea polyphenols, GTPs) has been shown to possess anti-inflammatory and anticarcinogenic properties in experimental animals. In this study we determined the effect of oral consumption of GTP on collagen-induced arthritis in mice. In three independent experiments mice given GTP in water exhibited significantly reduced incidence of arthritis (33% to 50%) as compared with mice not given GTP in water (84% to 100%). The arthritis index also was significantly lower in GTP-fed animals. Western blot analysis showed a marked reduction in the expression of inflammatory mediators such as cyclooxygenase 2, IFN- , and tumor necrosis factor in arthritic joints of GTP-fed mice. Histologic and immunohistochemical analysis of the arthritic joints in GTP-fed mice demonstrated only marginal joint infiltration by IFN- and tumor necrosis factor -producing cells as opposed to massive cellular infiltration and fully developed pannus in arthritic joints of non-GTP-fed mice. The neutral endopeptidase activity was approximately 7-fold higher in arthritic joints of non-GTP-fed mice in comparison to nonarthritic joints of unimmunized mice whereas it was only 2-fold higher in the arthritic joints of GTP-fed mice. Additionally, total IgG and type II collagen-specific IgG levels were lower in serum and arthritic joints of GTP-fed mice. Taken together our studies suggest that a polyphenolic fraction from green tea that is rich in antioxidants may be useful in the prevention of onset and severity of arthritis.

    2008-04-18 17:55:06 補充:

    也請參考這篇:Green Tea Can Help Prevent Rheumatoid Arthritis

    http://members.aol.com/goode200/green.tea.japanese...

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