1999年7月權威的美國國家科學院期刊"Proceeding of the National Academy of Science"科學性文章提出兒茶素有預防及減緩類風濕性關節炎作用~我想找此期刊的英文原文~
- Go_BadgersLv 71 decade agoFavorite Answer
1999年7月的美國國家科學院期刊無類似文章，但在同年4月13日的Vol. 96, Issue 8, 4524-4529, April 13, 1999，有一篇 "Prevention of collagen-induced arthritis in mice by a polyphenolic fraction from green tea", 是比較相關的論文。摘要如下：
Identification of common dietary substances capable of affording protection or modulating the onset and severity of arthritis may have important human health implications. An antioxidant-rich polyphenolic fraction isolated from green tea (green tea polyphenols, GTPs) has been shown to possess anti-inflammatory and anticarcinogenic properties in experimental animals. In this study we determined the effect of oral consumption of GTP on collagen-induced arthritis in mice. In three independent experiments mice given GTP in water exhibited significantly reduced incidence of arthritis (33% to 50%) as compared with mice not given GTP in water (84% to 100%). The arthritis index also was significantly lower in GTP-fed animals. Western blot analysis showed a marked reduction in the expression of inflammatory mediators such as cyclooxygenase 2, IFN- , and tumor necrosis factor in arthritic joints of GTP-fed mice. Histologic and immunohistochemical analysis of the arthritic joints in GTP-fed mice demonstrated only marginal joint infiltration by IFN- and tumor necrosis factor -producing cells as opposed to massive cellular infiltration and fully developed pannus in arthritic joints of non-GTP-fed mice. The neutral endopeptidase activity was approximately 7-fold higher in arthritic joints of non-GTP-fed mice in comparison to nonarthritic joints of unimmunized mice whereas it was only 2-fold higher in the arthritic joints of GTP-fed mice. Additionally, total IgG and type II collagen-specific IgG levels were lower in serum and arthritic joints of GTP-fed mice. Taken together our studies suggest that a polyphenolic fraction from green tea that is rich in antioxidants may be useful in the prevention of onset and severity of arthritis.
2008-04-18 17:55:06 補充：
也請參考這篇：Green Tea Can Help Prevent Rheumatoid Arthritis