During the anabasis of Alexander III, he fought against Darius III at Guagamela or Arbela: 331 BCE. The Medio-Achaemenids had 250,000 soldiers in total. Their front line consisted of the acontists and other light adscititious or auxiliary, kardakes which provided the main contingents of the Persian forces, longchophoroi or heavy cavalry, Bactrian and Sogdianan cataphracted pachyderms or armored war elephants, Grecian mercenaries and tribes from Pasargadae, Tapuria, Traxiane, Hyrcania and Hecatompylus. The Macedonians under Alexander III 'Eupator' had 45,000 soldiers with the main Macedonian phalanxes with a total of the tetraphalangiarchy being 28,687 phalangists, 8,192 prodromoi or light cavalry, 4,094 peltasts and acontists as skirmishers, and more psiloi and rorarii or light soldiers, followed by the tagmata and doryphoroi or the royal soldiers being the hypaspists.
Pyrrhus of Epirus who had 22,500 phalangists in his Epirote phalanxes composed of the Thresprotians, Molossians and Chaeonians, 3,000 kataphractoi or heavy cavalry used by the Hellenistic Diadochoi or 'Successors', 2,000 funditores or slingers and 20 pachyderms from his symmachia or alliance with first Demetrius I 'Poliorcetes': (Lord of Macedonia) and then Lysimachus (Lord of Thrace, Anatolia and Macedonia). Pyrrhus amalgamated and subjugated Illyricum, Tymphaea, Paravaea, Ambracia, Amphilochia and Acarnania, along with Corcyra that he received from Agathocles, Despot of Syracuse. During the Pyrrhic Wars: 280-275 BCE of the battles of Heraclea: 280 BCE, Ausculum: 279 BCE, Lilybaeum: 278 BCE and Beneventum: 275 BCE inimical against the Roman consuls of Publius Valerius Laevinus, Publius Decius Mus and Manius Curtius Dendatus, thousands of Romans, Libyo-Phoenicians (Carthaginians) and Epirotes perished.
The Carthanginians had 1,043 peltasts in the front line, 4,096 pikemen in the phalanx and 2,048 psiloi in the third and final line, with 512 heavy cavalry and light cavalry such as the Numidians, Libyo-Phoenicians, Lusatians and Celts on each flank.
Finally, the Graeco-Bactrian hegemon Eucratides I 'Eupator': 171-145 BCE who subjugated Demetrius II, Antimachus, Euthydemus II and Agathocles with 300 soldiers to the Indo-Greeks 60,000 soldiers. This conquest gave him an autarchy consisting of Tapuria, Traxiane, Hyrcania, Hecatompylus, Sogdiana, Ferghana, Bactria and Arachosia. Later Menander I 'Soter' seized control over Paropamisadae, Arachosia, the Punjab, Mathura, Gandhara all the way to Pataliputra.