小芳 asked in 社會與文化語言 · 1 decade ago

這是有關生理學的麻煩高手幫忙翻譯(請不要用網路直接翻謝謝)

Myelination in the central nervous system requires an accurate interplay between oligodendrocyte precursor cells (OPC) and axons. By as yet not fully understood mechanisms, OPC proliferate, migrate to the axon to be myelinated and finally differentiate into mature oligodendrocytes. The recent finding that OPC express CXC chemokine receptors led us to the investigation of the expression and functional importance of CC chemokine receptors. Using RT-PCR, we show that primary OPC from neonatal rats express CCR3, while CCR1, CCR2,CCR4, CCR5, and CCR7 are not expressed. Immunofluorescence staining of OPC could further demonstrate protein expression of CCR3. A rise of intracellular Ca2+ upon stimulation with the appropriate ligand CCL11 showed that this receptor is functional. Moreover, CCL11 led to a concentration specific increase in proliferation, inhibition of migration, and augmentation of differentiation in primary OPC. Thus, CCR3 may influence the process of myelination. This is of general importance for both developmental tissue patterning and for repair processes

in demyelinating diseases like multiple sclerosis.

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  • 1 decade ago
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    Myelination in the central nervous system requires an accurate interplay between oligodendrocyte precursor cells (OPC) and axons.

    中樞神經系統的髓鞘化要求寡樹突神經膠質前身細胞(OPC)與軸突之間一個精確的相互作用。

    By as yet not fully understood mechanisms, OPC proliferate, migrate to the axon to be myelinated and finally differentiate into mature oligodendrocytes.

    透過目前尚未全然清楚的機制作用,OPC會增殖、遷移到軸突而髓鞘化,到最後分化成成熟的寡樹突神經膠質細胞。

    The recent finding that OPC express CXC chemokine receptors led us to the investigation of the expression and functional importance of CC chemokine receptors.

    近期發現OPC傳遞CXC趨化激素受體引導我們朝向CC趨化激素受體的公式研究與函數重要性。

    Using RT-PCR, we show that primary OPC from neonatal rats express CCR3, while CCR1, CCR2,CCR4, CCR5, and CCR7 are not expressed.

    使用RT-PCR,我們證明來自新生幼鼠的主要OPC傳遞CCR3,而CCR1、CCR2、CCR4、CCR5與CCR7並未被傳遞。

    Immunofluorescence staining of OPC could further demonstrate protein expression of CCR3.

    OPC的免疫螢光染色更進一步論證了CCR3的蛋白質表現式。

    A rise of intracellular Ca2+ upon stimulation with the appropriate ligand CCL11 showed that this receptor is functional.

    在適合配體CCL11的刺激作用上細胞內Ca2+的增加證明了此受體是有作用的。

    Moreover, CCL11 led to a concentration specific increase in proliferation, inhibition of migration, and augmentation of differentiation in primary OPC.

    再者,在主要OPC上CCL11導向在繁殖、遷移抑制與分化增加率上集中具體的增加。

    Thus, CCR3 may influence the process of myelination.

    因此,CCR3可能影響髓鞘化的過程。

    This is of general importance for both developmental tissue patterning and for repair processes in demyelinating diseases like multiple sclerosis.

    這是在類似多發性硬化症之類髓鞘化疾病上的發育組織構造與修護過程的概略重點。

    2008-01-04 17:43:51 補充:

    中間關於CCL11、CCRx之類的,還有express的切確動作,因為不懂所以翻得較不通順,僅供你參考。

    Source(s): 參考一些講義然後自己翻譯
  • 1 decade ago

    James好強...都是高難度的挑戰

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