Characteristics of the Sampl翻譯
The characteristics of the sample are summarized in Table 2. The 66 patients (mean age 55 years, 58% men) were ethnically diverse: 59% black, 35% white, 3% Asian, and 1.5% Hispanic. Patients remained in the study for a mean of 4.2 days. A total of 37 patients (56%) remained in the study through day 4; 21 (32%), through day 7. Because patients remained in the study only while intubated and receiving mechanical ventilation, an important reason for attrition was extubation; death related to critical illness was another source of attrition. Most of the patients (65%) were intubated because of respiratory failure; the remainder were intubated to provide airway control.
Baseline counts of decayed, missing, and filled teeth (Table 2) indicated that many patients had oral health problems before admission. Interestingly, the number of times per day that oral comfort care was given did not affect day 4 CPIS (P = .81) and did not differ significantly between patients in whom VAP developed and those in whom it did not.
The risk of VAP as evidenced by mean CPIS consistently increased over time (Table 3). Of the 31 patients with complete data through day 4, a total of 8 (26%) had a score of 6 or higher on the CPIS.
Relationship Between Oral Health Status and VAP
Factors significantly related to day 4 CPIS were APACHE II scores (P=.007), day 4 salivary volume (P = .02), interaction between baseline CPIS and APACHE II (P<.001), and interaction between baseline CPIS and plaque (P =.01). An inverse relationship was observed between salivary volume and day 4 CPIS; as salivary volume decreased, CPIS increased. Because our model has 2 interaction terms (baseline CPIS × APACHE II and baseline CPIS × plaque), the effect of plaque on day 4 CPIS could not be directly interpreted.