? asked in 社會與文化語言 · 1 decade ago

急急急急急急....急需有人幫忙翻譯!!!!(鐵質吸收)

EFFECTS OF AGE AND MINERAL INTAKE ON THE REGULATION OF IRON

ABSORPTION IN INFANTS

Iron deficiency anemia during infancy is associated with delayed psychomotor and cognitive development; thus there is global interest in improving infant iron status through iron supplementation programs early in life.

In adults, iron homeostasis primarily is controlled through regulatory changes in iron absorption; however, there is little understanding of mechanisms that regulate iron absorption in infants.

As iron stores become depleted from rapid hemoglobin expansion, ontogenic transition to regulated iron absorption must occur.

To elucidate age-dependent mechanisms regulating intestinal iron absorption and homeostasis in human infants, studies in suckling rat pups indicated that increased divalent metal transporter 1 (DMT1), ferroportin 1 (FPN1), and hephaestin expression and changes in localization within the enterocyte may direct the ontogenic regulation of iron homeostasis mechanisms.

Unlike observations in adults, iron absorption, DMT1, and FPN1 expression were not affected by iron intake during mid-infancy, similar to observations in human infants.

Interestingly, at this age supplemental iron was retained in the small intestine, but only in pups that were not previously iron deficient.

Although intestinal retention may possibly help limit excess iron absorption, decreased linear growth, head circumference, and weight gain has been observed in iron-supplemented, nonanemic human infants, suggesting that global iron supplementation programs should be approached with caution.

可以的話翻順一點,我對英文一竅不通~"~

1 Answer

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  • 小高
    Lv 7
    1 decade ago
    Favorite Answer

    在對鐵的條例之上的效果

    在嬰兒的吸收

    鐵缺乏貧血在幼年期間與被延遲的精神運動而認知的發展有關; 如此有對經過在生活方面很早的鐵補充計畫改良嬰兒鐵狀態的全球興趣。

    在成人中,鐵體內平衡主要地透過鐵吸收方面的管制改變被控制; 然而,有在嬰兒中管理鐵吸收的機制的一點點理解。

    因為鐵商店從迅速的血色素擴充變成耗損, ontogenic 轉變到管理鐵吸收一定要發生。

    闡明年齡-依賴的機制在人類的嬰兒中管理腸的鐵吸收和體內平衡,研究在哺乳老鼠學生方面指出二價的金屬製的輸送人 1(DMT1) 、 ferroportin 1(FPN1) 和 hephaestin 表達增加和 enterocyte 裡面的本土化方面的改變可能指示鐵體內平衡機制的 ontogenic 條例。

    不像成人、鐵吸收、 DMT1 和 FPN1 表達的觀察不是被鐵攝取影響的在之中期間-幼年,類似人類的嬰兒觀察。

    有趣地,在這年齡補充的鐵在小腸中被保有,但是只有在不是先前的學生中燙不足的。

    雖然腸的維持也許有用限制過度鐵吸收,線的生長減少,頭圓周和重量增加已經在鐵中被觀察-補充,非貧血的人類嬰兒,建議全球的鐵補充計畫應該謹慎地被接近。

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