The mechanism of action of cranberry has prompted much scientific discussion. It was first hypothesized that acidification of the urine contributed to an antibacterial effect. The current proposed mechanism of action focuses primarily on cranberry’s ability to prevent bacterial binding to host cell surface membranes. In vitro studies have observed potent inhibition of bacterial adherence of Escherichia coli and other gram-negative uropathogens. Cranberry has been found to specifically inhibit hemagglutination of E. coli by expression of types 1 and P adhesin through the component compounds fructose and
Uses and Efficacy URINARY TRACT INFECTION
In the United States, one of every five women has been reported to have a lifetime incidence of UTI.Of these women, 3 percent experience recurrent disease. Eleven million women receive medication for UTIs annually. A recent Cochrane Database systematic review11 found no randomized trials assessing the effectiveness of cranberry juice in the treatment of UTIs and concluded that there is no evidence to support its use. There is much greater evidence-based information available for the use of cranberry in UTI prophylaxis. The first relatively large placebo-controlled studies, assessing efficacy were conducted in elderly women living in long-term care facilities. The findings of these studies12,13 showed that cranberry significantly reduced the frequency of bacteriuria and pyuria, but these were not intention-to-treat analyses. A 1997 study, published as a letter in The Journal of Family Practice, used a younger cohort of women and was the first study to use cranberry extract tablets rather than juice. Results showed that the cranberry concentrate was
more effective than placebo in reducing the occurrence of UTIs.
- 無聊的一天Lv 41 decade agoFavorite Answer
藥理蔓越桔的行動機制提示了科學討論。它第一次被假設, 尿的酸化對一個抗菌作用貢獻了。行動當前的提出的機制集中主要於蔓越桔的能力防止細菌捆綁對寄主細胞表面膜。體外研究觀察了大腸埃希氏菌和其它gram-negative uropathogens 細菌緊持的有力禁止。蔓越桔由表示型發現具體地禁止E. 桿菌的hemagglutination 1 並且P adhesin 通過組分配製果糖和proanthocyanidins 。
用途和效力尿道傳染在美國, 每五名婦女的當中一個被報告有UTI.Of 的終身發生這些婦女, 百分之3 經驗週期性疾病。十一百萬名婦女年年接受療程為UTIs 。一個最近Cochrane 資料庫系統的review11 沒有發現被隨機化的試驗估計蔓越桔汁的有效率在UTIs 的治療和認為, 沒有證據支持它的用途。有更加偉大的證據基於的有用的資料至於對蔓越桔的使用在UTI 預防。第一相對地大安慰劑被控制學習, 估計效力被舉辦了在年長婦女居住在長期關心設施。這studies12,13 的研究結果表示, 蔓越桔極大減少了bacteriuria 和pyuria 頻率, 但這些不是意圖對待分析。1997 研究, 被出版作為一封信件在家庭實踐學報, 使用了婦女更加年輕的一隊人和是第一研究用蔓越桔萃取物片劑而不是汁液。結果表示, 蔓越桔集中比安慰劑有效的在減少UTIs 發生。