Slow start up on computer! help!?

my computer takes quite awhile to start up, i've done the msconfig thing, and took off the unnecessary items, but what else could i do to help speed up the start up and help my computer work better, i've also done disk defrag. any websites or step by step instructions would be great.
Update: my computer is only a year old or so, i run anti virus and anti spyware stuff at least monthly, i just dont know why it takes over 5 minutes to start up
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