QB - Peyton is a fantasy stud no matter what scoring system you use. Jake Delhomme is a major weak-spot, but I wouldn't worry about it - he will only play during Peyton's bye week anyways.
RB - McGahee was a horse in Buffalo, and Baltimore fautres a more RB-friendly offense. Obviously it's an unproven variable, but he should do well for you. Benson and Bell are both question marks. Detroit is hardly an offensive powerhouse, and Benson isn't a viable 2nd back for a fantasy team. WM should be a good RB for you, though.
WR - I'd love to have Muhsin Muhammad on my REAL football team, but with Grossman at QB he's not a great fantasy WR. Your two rookies look good, especially Johnson. Anthony Gonzales is a solid player, but Indy does a great job of spreading the ball around. In a keeper league he might turn out, but this year he could be a bust. Moss has crazy talent, but if he turns into a mouthy jerk he might wear out his welcome. WR might be your biggest weak spot.
TE - Tony Gonzalez is the best fantasy tight end out there. End of discussion.
K - Who cares.
Def - Both Denver and Baltimore should suit you well. Defenses are hard to draft, so always play the matchup. If Baltimore plays Indy and Denver plays Oakland you should play Denver. Easy, right?