Human phaeomelanin production questions?
When stimulated by one of the cleavage products of proopiomelanocortin, typically α-melanocyte stimulating hormone (α-MSH), Mc1r initiates a complex signaling cascade that leads to the production of black or brown eumelanin. In most mammals, this signal can be altered by the binding of another protein to Mc1r. Agouti signaling peptide (Asip), a paracrine signaling factor, anatagonizes α-MSH activation of Mc1r and results in a switch to the production of red or yellow phaeomelanin. how can I bind Asip to Mc1r in humans?
- Sehr_Klug 50Lv 61 decade agoFavorite Answer
Rahther than modifying the Msc1 by insertion in the encoding DNA, its more practical, to kill slowly the melanocytes, with oxyquinolones, topically, in 2% concentration of hydrosuluble cream....... It takes about 4 months..and its effective.
Why are you so concerned into modifying in altering signals to the deep (basal ) layer of the epidermis?....its expensive and its madness....
There are other ways to block the main (alpha) melanocyte, without altering surrounding epidermal cells....iit is always better to work on the target, than modifying the signals of effectors (active pre melatonin stimulation), that is quite expensive, and demanding....
Lets use the practical side of the solution....Source(s): Certified neurosurgeon...
- Anonymous1 decade ago
The question is so baffling, this almost makes no sense.
The question is a little misguided, the area is complex enough without just ripping a passage from somewhere else, pasting it in and asking a relatively random question.
But anyhow. Asip does bind to human Mc1r receptors but this doesnt produce red hair as in all animals, infact it's effect can vary between all animals. Fact is that your hair colour (like most things in your body) are not under the sole jurisdiction of a single gene and many things are effecting hair/skin colour. And whilst Asip stimulating Mc1r may produce redish pigments, this is by no means an overwhelming factor.
People with ginger hair will almost always have quite pale fleshy skin also, this is because the Mc1r gene is mutated and so not working how it is supposed to in a human. Asip is still effecting it (among many things, actually. Asip is but one of the proteins that may cause productions). But in this case the Mc1r gene is mutated and so the protein for which it codes is altered in tertiary shape and thus function, essentially going a little overboard.