Examples of stem cells treatments in humans and ongoing researches or trials?
In addition to succesful or at least a little bit succesful applications currently done by stem cells, I wonder especially examples of treatment conbining gene therapy and stem cells? Could you give me some detailed information and related web site?
- 1 decade agoFavorite Answer
In a breakthrough trial, 15 young patients with newly diagnosed type 1 diabetes were given drugs to suppress their immune systems followed by transfusions of stem cells drawn from their own blood.
The results show that insulin-dependent diabetics can be freed from reliance on needles by an injection of their own stem cells. The therapy could signal a revolution in the treatment of the condition..
People with type 1 diabetes have to give themselves regular injections to control blood-sugar levels, as their ability to create the hormone naturally is destroyed by an immune disorder.
All but two of the volunteers in the trial, details of which are published today in the Journal of the American Medical Association (JAMA), do not need daily insulin injections up to three years after stopping their treatment regimes.
UW launches study testing adult stem cells for heart damage repair
The initial results from Phase I of the trial were encouraging,“ Raval says. ”Subjects reported feeling better with reductions in chest pain and improved exercise capacity during the early stage of the trial. That’s encouraging to us.“
Another Adult Stem Cell Breakthrough: Lupus Successes
Edjuana Ross, now 33, was diagnosed with the autoimmune condition known as systemic lupus erythematosus – lupus for short – soon after graduating from high school. She was one of 48 people who received the experimental therapy – a stem-cell transplant from her own bone marrow.
Ross said she has been in remission since recovering from her stem cell treatment done in 2003. “I’m just trying to get used to being well, and it’s a very weird feeling,” she said
Heart Disease - German heart specialist Bodo Eckehard Strauer successfully treated a heart patient, using stem
cells from the man’s bone marrow. Dr. Stauer said, "Even patients with the most seriously damaged hearts can be
treated with their own stem cells instead of waiting and hoping on a transplant" ("Stem cell therapy repairs a
heart," London Daily Telegraph, August 25, 2001).
Heart Disease - "Four out of five seriously sick Brazilian heart-failure patients no longer needed a heart
transplant after being treated with their own stem cells" ("Stem cells used to repair heart tissue," MSNBC News,
September 8, 2003)
From the research I have done it appears that use of stem cells can be used to treat most illness that affect the Human body.
Stem Cell & Gene Therapy
It is my understanding that the use of one's on stem cells. Represents the possibility of the sickness returning if
the problem is genetic. Then a combination Of gene therapy & stem cell is just a possibility likely to cure the condition, this dose not mean that it should be used.The third best way to treat the condition would be to remove the defective cells replacing them with healthy ones. Or if you could grow a replacement organ that would be second best. The best being never being sick or injured in the first place. From what I have read as of right now the FDA has not approved any form of gene therapy.
June 23, 2005 JOHNS HOPKINS SCIENTISTS USE GENE THERAPY TO PREVENT HEART ARRHYTHMIAS FROM STEM CELL TRANSPLANTS
Two clinical trials since 2002 using transplanted adult stem cells successfully led to tissue regrowth in damaged hearts, but 11 of 18 patients later developed potentially fatal heart rhythm disturbances, including one who required cardiac resuscitation. “It was a potential case of the cure being worse than the disease,” says senior researcher and cardiovascular physiologist Eduardo Marbán, M.D., Ph.D., professor and chief of cardiology at The Johns Hopkins University School of Medicine and its Heart Institute. “It was very discouraging to know that these patients developed arrhythmias, yet not know if it was the muscle stem cells at fault or simply a progression of the patients’ heart disease.”
Marbán is also editor in chief of the journal Circulation Research, in which the findings will be published online June 23.
Marbán’s team says it has discovered the source of the arrhythmias to be transplantation of myoblasts, which are adult stem cells taken from patients’ own healthy skeletal muscle. In patients, these myoblasts are injected directly into damaged heart muscle to regrow new tissue. In petri dish studies using these cells, the transplantation process caused an immediate disruption in heart muscle tissue’s regular electrical rhythm, or conductivity, which is necessary to stimulate a regular heart beat.
Moreover, the Hopkins group was able to minimize arrhythmias dramatically by using gene therapy to replace a key protein, called connexin 43, missing in heart muscle fibers that regrew as a result of the stem cell injections. Connexin 43 makes up the gap junctions between muscle cells, allowing cells to communicate with each other to regularly contract and expand.Source(s): http://www.signonsandiego.com/news/health/20070410... http://www.brightsurf.com/news/headlines/29320/UW_... http://www.lifesite.net/ldn/2006/feb/06020206.html http://stemcells.nih.gov/StemCells/Templates/StemC... gene therapy http://www.hopkinsmedicine.org/Press_releases/2005...
- 1 decade ago
a women in south korea was paralysed waist down for 40 years due to neuro muscular disjunction . after a 10week stem cell treatment she was able to walk with a walker and now is on her own two feet without any support.