Prednisone is a steroid used in the treatment in many autoimmune diseases. With a host of side effects moon face, weight gain from fluid and constant cravings. If you have been prescribed 6 prednisone tablets at 5 mg, I'm guessing you mean 30 mg daily, you can take 3 tablets at 10 mg, and get the same results. There is only one difference in the tablet formation, which is 5 mg tablets contain mineral oil in the make of the tablet and 10 mg tablets do not. As for the effectiveness it is the same. Remember to take this medication at the same time daily, morning is the best, since it makes you hyper and unable to sleep, and also DO Not miss a dose. Prednisone affects the Adrenal Gland and you can go into adrenal shock if you stop taking it suddenly or without being weened off. (There is only one exception, and you can not be on prednisone prior, taken in high dosage for one week only and then discontinued immediately). Your prescribed amount is fairly high to my knowledge, I know of patients taking 1mg to 5 mg daily, but also I have been on high dosages of 50 mg to 60 mg daily and weened down slowly. Talk to the Pharmacist when you pick up your presciption.