The most profitable business understands the art of filling a unique need, starting in a fairly localized market. (Of course, with e-commerce, the term localized has taken on new meaning).
But the most important feature of my answer is this: Make sure you love what you do. If not, you are simply using your seed money to purchase another "daily grind" job that doesn't make you smile when you wake in the morning.
Barbara Winter, known for being "Joyfully Jobless," and for writing the book *Making a Living Without a Job: Winning Ways For Creating Work That You Love*, coaches people to pursue the things they love and make a profit doing it. Perhaps you can grab her book and get the newsletter to help direct your investment choice.