Absolutely. The borrower executes the note to be secured against real property by a deed of trust and the terms of repayment are all spelled out. But before you sleep better at night, you need to know what else may be secured against the property, make sure he actually owns it, etc. You need to have the transaction formally handled by a closing agent, escrow officer, or attorney, depending on your State. That way, you will be provided with a title report, showing what liens are currently secured against the property, the condition of the taxes due on it, and any judgements against your borrower. You can get title insurance to make sure of the position of your loan and record a "Request for Notice" so you can be informed of any delinquencies. Then you must pay close attention that the loans secured against the property are paid current, because if those lenders foreclose and you don't notice, you could lose everything. This is best handled by professionals, because if you make a mistake on the documents, they may become unforeclosable.
15 yrs experience in closing real estate transactions