what is the pathophysiology of liver cirrhosis?

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  • 1 decade ago
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    Cirrhosis is characterized anatomically by widespread nodules in the liver combined with fibrosis. The fibrosis and nodule formation causes distortion of the normal liver architecture which interferes with blood flow through the liver. Cirrhosis can also lead to an inability of the liver to perform its biochemical functions. To understand the pathophysiology of cirrhosis, the normal anatomy and physiology of the liver must first be briefly reviewed.

  • 1 decade ago

    chronic inflammation will lead to zone necrosis & bridging fibrosis (both are purely pathological terms), & finally the development of Regenerating Nodules (with destruction of the normal liver architecture & of course liver function) causing increase in Portal Pressure (due to fibrosis in liver,this increase PP will cause complications like bleeding from the stomach..etc) along with accumilation of waste product in blood (since the hepaocytes can not perform its function & remove these toxic materials which will reach the brain causing Encephalpathy).

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  • 1 decade ago

    in cirrhosis there is some change in liver cells. liver cells are replaced by fibroblast cells. there are regenerative nodules scattered in it. thus liver becomes shrunken,nonfunctional. thus edema, jaundice,secondary infection , bleeding problems set in the body.

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