what does THC mean in marijuana?
i know its in marijuana but what does it mean in full term.
and wht effect does it have on the body.
- Anonymous1 decade agoFavorite Answer
Tetrahydrocannabinol, also known as THC, Δ9-THC, Δ9-tetrahydrocannabinol (delta-9-tetrahydrocannabinol), Δ¹-tetrahydrocannabinol (using an older numbering scheme), or dronabinol, is the main psychoactive substance found in the Cannabis plant. It was isolated by Raphael Mechoulam and Yechiel Gaoni from the Weizmann Institute in Rehovot, Israel in 1964. In pure form it is a glassy solid when cold and becomes viscous and sticky if warmed. THC has a very low solubility in water, but a good solubility in most organic solvents such as ethanol or hexane. As in the case of nicotine and caffeine, THC's most likely function in Cannabis is to protect the plant from herbivores or pathogens .
Its pharmacological actions are the result of its binding to the cannabinoid receptor CB1, located in the brain. The presence of these specialized receptors in the brain implied to researchers that endogenous cannabinoids were manufactured by the body, so the search began for a substance normally manufactured in the brain that binds to these receptors, the so-called natural ligand or agonist, leading to the eventual discovery of anandamide, 2 arachidonyl glyceride (2-AG) and other related compounds. This story resembles the discovery of the endogenous opiates (endorphins, enkephalins, and dynorphin), after the realization that morphine and other opiates bound to specific receptors in the brain.
THC has analgesic effects even at low doses that do not cause a "high", and cannabis was once commonly used to treat pain. Other effects include: relaxation; euphoria; altered space-time perception; alteration of visual, auditory, and olfactory senses; disorientation; fatigue; and appetite stimulation. It also has anti-emetic properties, and also may reduce aggression in certain subjects.
THC has a LD50 value of 1270 mg/kg (male rats) and 730 mg/kg (female rats) administered orally dissolved in sesame oil.
If this were scaled up to an adult human, the lethal dose would be between approximately 50 and 86 g for a 68 kg (150 lb) female or male person respectively. This would be equivalent to 1-1.8 kg of cannabis with a 5% THC content (roughly average) taken orally (much more if smoked). It is important to note, however, that toxicity studies in animal models do not necessarily correlate to human toxicity. THC receptor distribution in the rat CNS is different from that of humans, meaning that there is the significant possibility that toxicity in humans varies from the published animal LD50 studies. There has never been a documented fatality from marijuana or THC overdose.
Studies of the distribution of the cannabinoid receptors in the brain explain why THC's toxicity is so low (i.e., the LD50 of the compound is so large): parts of the brain that control vital functions such as respiration do not have many receptors, so they are relatively unaffected even by doses larger than could ever be ingested under any normal conditions.
- 1 decade ago
Both of your previous answers are correct... the first regarding drug tests and second regarding pharmacology.
From a very simple perspective, this is one of lots and lots of chemicals inside of marijuana. In fact, it's the most important. It's the one that triggers the high.
It makes you generally: hungry, happy, giggly, and imaginative. It also helps you not remember being any of these. Many people get anxious and paranoid.
THC is marijuana. In fact, they have created synthetic THC pills extracted from marijuana (also illegal). They have pretty much the same effect as smoking marijuana. Therefore, from a 'user' perspective THC and marijuana are pretty much interchangable. (THC being inside of marijuana)
- Anonymous4 years ago
not directly, but it does mean that it stays in your body longer than just day or 4. THC stimulates a neuroreceptor that makes people want to eat, ie the munchies.
- Anonymous1 decade ago
It is the active ingredient that makes you high. This is what is stored in fat cells for 30 days and causes people to fail drug tests.