There is a common belief that the need for God as an explanation of the unknown has been eliminated by science. This may well be so, but not all religions believe in a 'God of the gaps'.
Buddhism can get along quite happily without needing to speculate on the existence or non-existence of a First Cause. The real threat to all religions comes not from the closing of the gaps which God used to occupy (such as origin of the species), but from the doctrine of mechanistic materialism, which teaches that there is no spiritual dimension to human life. Buddhism at present seems to be the only coherent philosophical system which is capable of resisting materialism and emphasising human spiritual potential.
Buddhism is the only major religion which acknowledges a large area of ignorance about external matters. Unlike other religions, it does not even attempt to answer questions like 'What is the purpose of life, the universe and everything?' . Buddhism regards such questions as at best unanswerable and probably intrinsically meaningless. The only purpose of life is what we personally give to our own lives. Buddha suggested that the most meaningful use of life was to seek liberation from ignorance, suffering and the cycle of samsaric rebirth, both for one's self and others. But this 'meaning' does not reside 'in the sky' or in any way outside of the individual, and it cannot be imposed, but must be freely chosen.
Most other religions go further than Buddhism, and if asked 'What is the purpose of life, the universe and everything?' will usually come up with an answer along the lines of 'To fulfil the will of God.'
This invites the further question of 'What is the will of God', which usually brings forth an answer to the effect that 'God's will is to create life, the universe and everything'.
Buddhism is the one exception and is quite happy with the theory of evolution. In fact Buddhist philosophy actually requires evolution to take place - all things are seen as being transient, constantly becoming, existing for a while and then fading.
Most religions teach that they are the one true path to salvation and all those people who chose (or were brought up in) the wrong paths will be judged by the True Religion's Founder and thrown into hell. This doctrine is known as exclusivism or judgementalism. Buddhism is not exclusivist. To a Buddhist any person guided in their activities by compassion is regarded as following a beneficial spiritual path.