阿樂 asked in 社會與文化語言 · 1 decade ago

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A New Sodium Hyaluronate

The concentration of HA in rooster

combs and human umbilical cords is very high, reaching 7500 mg/L and

4100 mg/L, respectively, in the early 1980s,Balazs and coworkers developed a

proccdure to isolate,purify and identify hyaluronic acid from rooster combs and

human umbilical cords. Since then, HA has been produced from rooster combs

at industrial scale. However, the rooster comb-based extraction process is faced

by a growing concern over the use of animal-derived products for technical

and especially biomedical applicavions.Hence, microbial fermentation has

emerged as a new technique for the production of HA.

The bacterial production of HA involving a Streptococcus zooepidemicus strain was first described in 1989,

giving rise to the first commercializa-tion of biosynthetic HA. Nevertheless,

streptococci are pathogenic in nature. In addition, they are fastidious lactic acid

bacteria with demanding requirements such as media enriched in proteins

during the fermentation. The presence of bacterial endotoxins, chondroitin

sulfates, proteins, nucleic acids and heavy metals in HA from streptococcal

fermentation or rooster combs has alsobeen reported. Finally, both extracted

HA and microbial HA are purified using harsh organic solvents.

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  • 1 decade ago
    Best Answer

    新鈉HA 集中在雄雞梳的Hyaluronate 並且人的臍帶是非常高的, 到達7500 mg/L 並且4100 mg/L, 各自地, 在80 年代初期、Balazs 和工友開發一proccdure 隔絕, 淨化和辨認hyaluronic 酸從雄雞梳子和人的臍帶。從那以後, HA 由雄雞梳子導致了在工業標度。但是, 雄雞基於梳子的提取過程由對對動物被獲得的產品的用途的增長的關心面對為技術並且特別是生物醫學的applicavions.Hence, 微生物發酵湧現了作為HA 的生產的一個新技術。1989 年HA 的細菌生產介入鏈球菌zooepidemicus 張力第一次被描述了, 提升生物合成的HA 的第一商品化。然而, 鏈球菌是致病性在自然裡。另外, 他們是吹毛求疵的乳酸細菌以demanding 要求譬如媒介被豐富在蛋白質裡在發酵期間。細菌內毒素出現, 軟骨素硫化, 蛋白質、核酸和重金屬在HA 從鏈球菌

    發酵或雄雞梳子有alsobeen 報告。終於, 提取的HA 和微生物HA 被淨化使用苛刻的有機溶液。

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