role of ssri in diabetic neuropathy
- Anonymous1 decade agoFavorite Answer
Treatment of early manifestations of sensorimotor polyneuropathy involves improving glycemic control. Tight control of blood glucose can reverse the changes of diabetic neuropathy. Despite advances in the understanding of the metabolic causes of neuropathy, treatments aimed at interrupting these pathological processes have been limited by side effects and lack of efficacy. . The drugs- imipramine, amitriptyline, desipramine and nortriptyline- are effective at decreasing painful symptoms but suffer from multiple side effects that are dosage dependent. One notable side effect is cardiac toxicity, which can lead to fatal arrhythmias.
SSRIs (Selective serotonin reuptake inhibitors) include fluoxetine, paroxetine, sertraline and citalopram. They are less effective in relieving pain, but are better tolerated. Side effects are rarely serious, and do not cause any permanent disabilities. They cause sedation and weight gain, which can worsen a diabetis's glycemic control.
"The SSNRI Duloxetine (Cymbalta) is approved for Diabetic neuropathy."
By targeting both Serotonin and Norepinephrine. It targets the painful symptomes of diabetic neuropathy, and also treats depression if it exists.
Carbamazepine (Tegretol®) is effective but not necessarily safe for diabetic neuropathy. Its first metabolite, oxcarbazepine, is both safe and effective in other neuropathic disorders, but has not been studied in diabetic neuropathy.
- Anonymous4 years ago
Home Treatment For NeuropathySource(s): https://tinyurl.im/aH9Jp
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- 1 decade ago
SSRIs or Selective Serotonin Reuptake Inhibitors are a group of drugs mainly used in treating depression, but recent trials have indicated that they may be useful in treating diabetic neuropathy as well, due to their action on GABA receptors.
Now... there are different drugs in this group -- the most widely known being fluoxetine or prozac, which appears effective only in diabetic neuropathy with co-existing depression.
Paroxetine and fluvoxamine appear to have some efficacy in diabetic neuropathy. SSRIs were the 1st to be FDA approved in the treatment of diabetic neuropathy.
In general, however, they are less efficacious than tricyclic antidepressants. The mainstay of treatment, however, remains at controlling the diabetes itself and of course, as the old adage goes -- PREVENTION is better than cure.
K... now may I have my 10 points? :-)
- Anonymous6 years ago
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- Anonymous5 years ago
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- 1 decade ago
my mother unfortunatly has neuropathy-she takes neurotin for the tremendous pain she is in.There is no cure for neuropathy and some people have it worse than others.Both my moms parents had diabetes and neuropathy but she is worse off-they all have(had)CHF,PAD.My mom is 52 years old and b/c she has had 5 heart attacks and 3 strokes her heart is working at 20% now.Doctors have said if she has a big heart attack it will take her life b/c she is so weak.Best wishes