Do your homework, know what your credit is like because that will matter on the interest rates and your payments. Its a good buyers market now, and sellers will sometimes help with closing costs if you ask. Other fees can be wrapped back into the loan so you can buy with no money down. But be sure you understand the points (additional amount you will pay for the loan) and if the loan will have a pre-payment penalty. Do not go with any ARM loans right now, and do not use the negative ARMS especially. Go with fixed rates only.
When you do find a home you like, pay for a home inspection so that you know what your buying. Also have a home warrenty added so that if anything breaks in the future your not putting out even more large amounts of money. This again is something sellers will offer you. They run about $350 to $450 per year and can be a great investment when your buying a home you dont know well yet.
Good Luck to you, I hope you will find a great home soon.