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Anonymous
Anonymous asked in 科學生物學 · 1 decade ago

請問:什麼是housekeeping gene?

請問一下:

什麼是housekeeping gene?

其定義詳細解釋為何?

謝謝^^

2 Answers

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  • 1 decade ago
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    housekeeping gene它包含了提供細胞基本營養的功能,且此段基因幾乎是不被Enzyme所抑制,也就是此段基因的功能是幾乎永遠開啟的!

    此段基因所(transcribed)轉錄出來的蛋白質具有固定的level;也因為此段的表現並不會受到外在(實驗)環境所影響,所以常被用於大量PCR的內在標準(internal standards)!

    在此舉例一些廣泛被利用的housekeeping genes:

    1.aldolase (醛縮酶 )

    2.GAPDH (甘油醛-3-磷酸脫氫酶)

    3.actin (肌動蛋白)

    4.cyclophilin (CyP)(一種免疫系統蛋白)

    5.hexokinase (六碳糖激酶)

    Source(s): Lehninger
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  • 1 decade ago

    +1

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