Is it regulated/advised when the airline pilots has to use the autopilot and when they can/must go manual?

As nowadays the advanced integrated electronic systems theoretically allow passenger planes to fly without human interactions (only ATC is not automated, when that will happen anyway?), it is a question to me, how much fun remains for pilots? Obviously there are situations when the decision on usage of autopilot... show more As nowadays the advanced integrated electronic systems theoretically allow passenger planes to fly without human interactions (only ATC is not automated, when that will happen anyway?), it is a question to me, how much fun remains for pilots?
Obviously there are situations when the decision on usage of autopilot is simple: FMS failure or very low visibility with heavy turbulences etc.
But what about the rest? Is it the captain's decision to manually fly the plane when landing on a shiny day?
Is it differently regulated by airlines?Or FAA? Or only advised not regulated?
I expect the autoland to be more safe than manual. But if we don't let the pilots fly manually, they might go out of practice for cases when it is really them who has to drive, due to an emergency (did such situation ever happened at all...!?).
Or look at the sad situation of the greek plane last year, every flight system was operational,but AP was programmed to circle, not to land, before pilots went unconscious.
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