Concern with taking Vit.E with Lipitor.?
On Lipitor 20mg.(recently) for 20-30% carotid blockage. Dr. said not to take Vit. E as it negates effects. Can't find this info anywhere. Opinion please.
- ashleyligon1967Lv 51 decade agoFavorite Answer
The New Vitamin E Heart Disease Study
and Associated Media Circus
Most of you have certainly seen the news reports on the recent HOPE-TOO study in the Journal of the American Medical Association (JAMA) suggesting that vitamin E may actually increase risks rather than protect against heart disease. The urgency and intensity with which it is being presented suggests one of three things. There is a scarcity of important news, and hyping material like this is the only way to boost ratings. It furthermore gives the public the impression that these diligent newscasters are literally saving our lives with important information, and that we had best keep our TV tuned to that station for more and future life changing stories. Or perhaps, the study clearly and really points to a new direction in our use and thinking about vitamin E in heart patients. Then again, maybe the media is controlled by the people that would rather you take Lipitor and Zocor and other expensive drugs rather than vitamins. So perhaps they take studies that are adverse to natural medicine treatment, report them out of context, and hype them to the hilt. That’s a possibility also.
The connection between antioxidant status and good health has been one of the most studied and well established scientific theories ever proposed. Specifically, there is also a huge literature database of studies (over one thousand), many of then extremely large, that clearly document the protective effect of vitamin E versus heart disease and other health problems. The classic heart study was the NEJM study that showed an up to 80% reduction in heart disease risk in those taking vitamin E supplements. The Harvard Nurse’s Health Study of 87,000 individuals also showed a 41% reduction in heart disease risk in those taking vitamin E as a supplement for at least two years. Possible mechanisms of action are free radical fighting, anti-arteriosclerosis effect, and reduction of CRP and IL-6 inflammation markers. It has also been clearly shown that most of the population ingests an inadequate amount of vitamin E through their diet alone, Vitamin E also has multiple other body-wide benefits including reduction of certain cancers, protection against lipid oxidation, protection of the brain, and reduction of skin aging, It is also imperative that extra vitamin E be taken when individuals are supplementing their diet with the popular fish oil or other oil supplements. It should also be noted that vitamins work best when they are taken in the form that most closely resembles its naturally occurring form. In the case of vitamin E, most medical studies (the quoted prior two and the current one) have employed only the d-alpha component of vitamin E. We now know that vitamin E is a mixture of 4 different tocopherols, with the gamma form having potentially the most potent health promoting effects on the blood and heart. Using pure alpha tocopherol can actually depress gamma tocopherol levels in the body.
This might be a partial explanation for the apparent lack of protective effects in the sicker patients of the HOPE-TOO study now under consideration. Here at CMRS we only prescribe the mixed tocopherol form of vitamin E.
The latest vitamin fear mongering being cast upon an unsuspecting public is being done specifically against the cautionary comments of the HOPE-TOO study authors themselves. In a fairly small population (3994) of elderly, high risk, and highly medicated patients, their data suggested a lack of protective effect of vitamin E and a slight possibility of increased risk of congestive heart failure in this group when vitamin E was supplemented at 400 IU per day. The authors stated clearly that these results were unexpected, could have occurred by chance (were not statistically significant), and are not supported by existing trials. I would also add that I wouldn’t expect to see dramatic changes from adding Vitamin E alone in this particular group of patients. Despite that, we see the supposed new dangers of vitamin E (for EVERYONE) being plastered all over the airwaves.
My thought is that there is awesome literature support of the health benefits of taking supplemental vitamin E for both healthy and ill populations. The authors admit that this study does not change that. The media cannot be trusted to report scientific news related to medical alternatives (and many other things) without political and economic bias. Think for yourself, or find a physician you trust that can help you sort out the wheat from the chaffe.Source(s): http://www.cmrsnews.com/vitamin_e1.htm
- ckm1956Lv 71 decade ago
Contrary to a previous answer, there is NO widely accepted studies that have shown a reduction in morbidity or mortality from taking vitamin E. On the other hand, there IS good evidence for Lipitor & similar drugs.Source(s): vascular surgical PA