Liz
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Liz asked in 社會與文化語言 · 1 decade ago

英文翻譯 可以幫我翻譯本文意思嗎?

The arteriovenous polytetrafluoroethylene (PTFE) graft has

been widely used as long-term vascular access for chronic

hemodialysis.1–3 Unfortunately, graft complications remain a

leading cause of morbidity in hemodialysis patients. Graft

failure occurs because of two primary reasons: thrombosis

(80% of cases) and infection or other complications (20%).4,5

Thrombosis results from neointimal hyperplasia and subsequent

stenosis at the anastomosis between the graft and

normal vasculature. These are mainly induced by excessive

proliferation and migration of vascular smooth muscle cells

(SMCs) upon vessel injury due to graft implantation. They

can also occur because of flow disturbance at the anastomosis.

6,7

Previous efforts have been directed toward early treatment

of the stenosis by percutaneous angioplasty, which turned out

to neither improve graft survival nor reduce the graft thrombosis.

8,9 Thus the long-term key to graft viability is to prevent

stenosis. Current strategies to prevent graft stenosis include

gene, radiation, and drug therapy.10 In gene therapy, particular

attention has been given to the use of an oligodeoxynucleotide

(ODN) that binds transcription factor (E2F),

which controls the expression of multiple genes that are

responsible for progression of the cell cycle in proliferating

cells. Clinical trials have demonstrated the safety and feasibility

of intraoperative transfection of native bypass vein

grafts with the E2F decoy ODN during surgery, and suggests

the possibility of biological efficacy.11,12 But it is still not

Contract grant sponsor: Merit Review Program of the Department of Veterans

Affairs

135

clear whether this strategy would be effective for PTFE graft

and whether a single application would be sufficient for

long-term prevention because the graft is subjected indefi-

nitely to stimuli for cell proliferation through blood flow

disturbance and upstream needle puncture.

ps:尋求paper高手 救我阿

Update:

不要用翻譯軟體

我只要知道大概內容就可以了

1 Answer

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  • 1 decade ago
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    arteriovenous polytetrafluoroethylene(PTFE) 嫁接

    被作為慢性的長期的血管的出入口廣泛地使用

    hemodialysis。 1 不幸,嫁接錯綜複雜保持A

    hemodialysis 病患的病狀的主要原因。 嫁接

    因為兩個主要原因,失敗發生︰ 血栓形成

    (80%的情況) 以及感染或者其他併發症(20%) . 4,5

    血栓形成起因於neointimal 增生和隨後

    stenosis在吻合在嫁接之間和

    正常的vasculature。 過度主要引起這些

    血管的平滑肌細胞的發展和遷移

    (SMCs) 在管傷上由於嫁接種植。 他們

    因為在吻合的流動騷動,也能發生。

    6,7

    以前的努力致力於盡快處理

    在stenosis 以percutaneous血管成形術中,變

    既不改進嫁接生存也不降低嫁接血栓形成。

    8,9 如此長期的嫁接生存能力的關鍵是防止

    stenosis。 防止嫁接的當今的策略 stenosis 包括

    基因,輻射和藥物療法。 在基因治療,細節過程中的10

    注意已經被給到oligodeoxynucleotide的用途

    (ODN) 那捆抄寫原素(E2F) ,

    哪個控制是的多基因的表示

    在增生過程中對小屋循環的前進負責

    小屋。 臨床試驗已經證明安全和可行性

    本地支路靜脈的intraoperative transfection

    在手術期間的與E2F 誘餌ODN的嫁接,和建議

    生物學的效力的可能性。 但是它不仍然是11,12

    合約准許發起人︰ 功績評論老戰士部門的計畫

    事務

    135

    清楚是否這個策略將對於PTFE嫁接有效

    並且是否單個的應用將是對於足夠的

    長期的預防因為嫁接是被征服的indefi

    細胞發展的刺激的nitely透過血流動

    騷動和向上游針胎環穿孔。

    Source(s):
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