英文翻譯 可以幫我翻譯本文意思嗎?

The arteriovenous polytetrafluoroethylene (PTFE) graft has been widely used as long-term vascular access for chronic hemodialysis.1–3 Unfortunately, graft complications remain a leading cause of morbidity in hemodialysis patients. Graft failure occurs because of two primary reasons: thrombosis (80% of cases) and... show more The arteriovenous polytetrafluoroethylene (PTFE) graft has
been widely used as long-term vascular access for chronic
hemodialysis.1–3 Unfortunately, graft complications remain a
leading cause of morbidity in hemodialysis patients. Graft
failure occurs because of two primary reasons: thrombosis
(80% of cases) and infection or other complications (20%).4,5
Thrombosis results from neointimal hyperplasia and subsequent
stenosis at the anastomosis between the graft and
normal vasculature. These are mainly induced by excessive
proliferation and migration of vascular smooth muscle cells
(SMCs) upon vessel injury due to graft implantation. They
can also occur because of flow disturbance at the anastomosis.
6,7
Previous efforts have been directed toward early treatment
of the stenosis by percutaneous angioplasty, which turned out
to neither improve graft survival nor reduce the graft thrombosis.
8,9 Thus the long-term key to graft viability is to prevent
stenosis. Current strategies to prevent graft stenosis include
gene, radiation, and drug therapy.10 In gene therapy, particular
attention has been given to the use of an oligodeoxynucleotide
(ODN) that binds transcription factor (E2F),
which controls the expression of multiple genes that are
responsible for progression of the cell cycle in proliferating
cells. Clinical trials have demonstrated the safety and feasibility
of intraoperative transfection of native bypass vein
grafts with the E2F decoy ODN during surgery, and suggests
the possibility of biological efficacy.11,12 But it is still not
Contract grant sponsor: Merit Review Program of the Department of Veterans
Affairs

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clear whether this strategy would be effective for PTFE graft
and whether a single application would be sufficient for
long-term prevention because the graft is subjected indefi-
nitely to stimuli for cell proliferation through blood flow
disturbance and upstream needle puncture.

ps:尋求paper高手 救我阿
Update: 不要用翻譯軟體
我只要知道大概內容就可以了
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