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? asked in 科學生物學 · 2 decades ago

受器VCAM-1及 E-selectin是什麼?

 受器VCAM-1(vascular cell adhesion molecule-1)及E-selectin,個別具有哪種功能?

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  • 2 decades ago
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    VCAM-1 (vascular cell adhesion molecule-1), or CD106, 具有6-7個immunoglobulin免疫血球素 domains並且在內皮細胞受cytokines細胞質分裂刺激後在大小血管表現。VCAM-1持續表現超過24小時。VCAM-1是個endothelial ligand for VLA-4 (Very Late Antigen-1 or α4β1) of the β1 subfamily of integrins and for integrin α4β7. VCAM-1促進黏著lymphocytes淋巴球, monocytes單核白血球, eosinophils嗜伊紅血球, and basophils嗜鹼細胞。有趣地,某些melanoma cells黑色素瘤細胞可利用VCAM-1黏附內皮,且VCAM-1可能參與吸引monocyte單核白血球至atherosclerotic動脈粥狀硬化位置. 因此, VCAM-1是一個有潛力的藥物目標。 

    為細胞黏著分子及CD antigen使嗜中性白血球 neutrophil, 單核白血球monocyte, and記憶型T細胞 memory T-cell黏著於細胞質分裂刺激後的內皮細胞. E-selectin recognizes sialylated carbohydrate groups related to the Lewis X or Lewis A family.

    2006-05-01 08:21:05 補充:

    下方的是E-selectin

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