- TigerLv 52 decades agoFavorite Answer
There is one good reference about nuclear pore from Scripps Institute in San Diego:
<http://www.scripps.edu/~stoffler/proj/NPC/npc.html... You can see the illustration and figures there as well.
The Nuclear Pore Complex
Molecular trafficking between the nucleus and the cytoplasm of interphase cells occurs via the nuclear pore complexes (NPCs), large supramolecular assemblies that are embedded in the double-membraned nuclear envelope (NE). The NPCs provide peripheral channels of about 9 nm in diameter, which allow the diffusion of ions and small molecules, and mediate the selective transport of nuclear proteins, RNAs, and ribonucleoprotein (RNP) particles by energy-dependent mechanisms.
The structure of the NPC has been extensively investigated by electron microscopy (EM), and a consensus model of its central framework has emerged (Fig. 2). Accordingly, the vertebrate NPC exhibits an 8-fold symmetric (i.e., perpendicular to the plane of the NE) tripartite architecture with a total mass of ~125 MDa. Its ~55 MDa central framework is a ring-like assembly built of eight multi-domain spokes consisting of two roughly identical halves each so that its asymmetric unit (i.e., one half-spoke) represents one 16th of its mass or roughly the size of a ribosome. This central framework is sandwiched between a ~32 MDa cytoplasmic ring and a ~21 MDa nuclear ring. From the cytoplasmic ring eight short, kinky fibrils emanate, whereas the nuclear ring anchors a basket (or fishtrap), assembled from eight thin, ~50 nm long filaments joined distally by a 30- to 50-nm-diameter ring. The ring-like, ~822-symmetric central framework embraces the central pore of the NPC which acts as a gated channel. The central pore is often plugged with a distinct particle, called central plug or transporter, of highly variable appearance whose molecular architecture and functional significance remain to be established.
2006-04-09 19:54:19 補充：
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- 超導狂人Lv 72 decades ago
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