宏瑋 asked in 科學生物學 · 1 decade ago

[生物問題]請問各位大大什麼是 caveolae ??

今天老師給我們出了一個題目~

問我們何謂caveolae

我只知道那是膜上的一種脂筏(lipid rafts)...

拜託為我解惑^o^

Update:

不好意思 可以給我中文的回答嘛??

謝謝~!!

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  • 1 decade ago
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    ca·ve·o·la (kă-vē'ə-lə)n., pl. -lae (-lē'). A small vesicle, or recess, especially one communicating with the outside of a cell and extending inward, indenting the cytoplasm and the cell membranecaveolae In biology, caveolae (Latin for little caves) are small (50 - 100 nanometer) invaginations of the plasma membrane in many cell types, especially in endothelial cells. Some cell types, like neurons, may completely lack caveolae.These flask-shaped structures are rich in proteins including caveolins and lipids such as cholesterol and sphingolipids and have several functions in signal transduction (Anderson, 1998). They are also believed to play a role in endocytosis, oncogenesis, and the uptake of pathogenic bacteria (Li et al., 2005). Caveolae are one source of clathrin independent endocytosis involved in turnover of adhesive complexes.Formation and maintenance of caveolae is primarily due to the protein caveolin. This protein has both a cytoplasmic C-terminus and a cytoplasmic N-terminus, linked together by a hydrophobic hairpin that is inserted into the membrane. The presence of caveolin leads to the local change in morphology of the membrane.Because of their specific lipid content, caveolae are sometimes considered as a caveolin-positive subset of lipid rafts.http://www.answers.com/caveolae

    2006-03-15 11:38:00 補充:

    sorry, 字數超過了, 請見:

    http://gene.bjmu.edu.cn/science/download/6.doc

    胞膜窖(caveolae)是1953年由Palade在電子顯微鏡下發現的,當時命名爲plasmalemmal vesicles。兩年後,Yamada將其命名爲Caveolae,用以描述這種細頸瓶狀的細胞膜內陷。

    2006-03-15 11:38:35 補充:

    胞膜窖是細胞膜上特定的,直徑約50-100nm的微區域(microdomain),富含膽固醇、鞘磷脂(sphingomyelin)和鞘糖脂(glycosphingolipids),形成一個去垢劑不溶性的膜區域,並且以存在窖蛋白(caveolin)分子爲特徵;它們也可以在細胞膜上或平鋪,或管狀,或形成分離的小泡,並且融合成>100nm的結構。

    2006-03-15 11:39:01 補充:

    胞膜窖大量存在于內皮細胞、脂肪細胞、血管平滑肌細胞、纖維母細胞和肺上皮細胞。傳統上認爲,胞膜窖在細胞transcytosis和potocytosis(鞘糖脂肌醇錨定受體參與的細胞內吞作用)中起重要作用。隨著分子生物學研究的進展,發現胞膜窖參與許多細胞生命活動,例如細胞內吞(endocytosis)、膽固醇運輸、細胞膜組裝、信號傳導和腫瘤生成等。

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