醫療--營養學翻譯

Recent research: Phase I of the Trials of Hypertension Prevention (a multicenter, randomized controlled trial) demonstrated, over an 18 month period, the ability of moderate sodium reduction (from 155 to 100 mmol per day) to lower the mean systolic and diastolic blood pressure of 30-54 year old adults who had a... show more Recent research: Phase I of the Trials of Hypertension Prevention (a multicenter, randomized controlled trial) demonstrated, over an 18 month period, the ability of moderate sodium reduction (from 155 to 100 mmol per day) to lower the mean systolic and diastolic blood pressure of 30-54 year old adults who had a high normal diastolic blood pressure at the time of enrollment. This group average blood pressure resulted in a 25% reduction in the number of individuals who developed high blood pressure during the study period. The Trials of Hypertension Prevention, Phase II, included a test of the ability of sodium reduction (without weight loss) to lower mean systolic and diastolic blood pressure in a group of adults who were overweight, over a longer follow up period (36-42 months). Compared to the usual care group (n=596), the chances of developing hypertension were lower in those assigned to sodium reduction (n=594) compared to those assigned to usual care (no dietary intervention) (relative risk or RR) for sodium versus usual care = 0.61, p=.04 at 6 months; RR=0.88; p=0.28 at 18 months; RR=0.88, p=0.09 at 36 months, and RR=0.86, p=.04 for those followed through 48 months. Urinary sodium excretion data collected at each time point suggest that the smaller effect on blood pressure from 18-months on reflects the difficulty in achieving sufficient long term adherence to sodium reduction.

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