Anonymous asked in 社會與文化語言 · 1 decade ago


IL-10 binds to a member of the cytokine receptor

family that signals through the Jak/STAT3-pathway [27].

It finally transmits the anti-inflammatory and immune

effects of IL-10 by induction of suppressor of cytokine

signalling-3 and -5 (SOCS-3 and -5) [27]. SOCS-3

inhibits the transcription of pro-inflammatory cytokines

and genes stimulated by them. In addition, metabolic

effects like hepatosteatosis and insulin resistance could be

induced by hepatic overexpression of SOCS-1 and SOCS-

3 in mice [28]. Direct blockers of the IL-10-receptor are

not available. We therefore used piceatannol, a specific

inhibitor of the proximal Jak1/Tyk2/STAT3/5 pathway

[29,30]. Piceatannol abolished the stimulation of ABCA1

by IL-10, but did not affect baseline expression ofABCA1. Thus, the IL-10 stimulation of ABCA1 is

proximally transmitted via the classic IL-10 pathway,

but IL-10 is not relevant for baseline ABCA1 expression

in macrophages. A STAT-binding site in the ABCA1

promoter at 350 bp ( offers a

potential direct link from the IL-10-receptor pathway to

ABCA1 expression. But this binding motif is not STAT3

specific and may integrate signals from several cytokine




3 Answers

  • Anonymous
    1 decade ago
    Favorite Answer

    IL-10 receptorfamily 束縛對cytokine 的成員信號通過Jak/STAT3 路[ 27].It 最後傳送IL-10 抗發炎和immuneeffects 由遏抑器的歸納cytokinesignalling-3 和-5 (SOCS-3 和-5) [ 27 ] 。SOCS-3.inhibits 讚成激動cytokinesand 基因的副本由他們刺激。另外, metaboliceffects 像hepatosteatosis 和胰島素抗性能beinduced 由SOCS-1 和SOCS-3 肝overexpression 在老鼠[ 28 ] 。IL 10 感受器官arenot 的直接預鍛模可利用。我們使用了因此piceatannol, 接近Jak1/Tyk2/STAT3/5 的specificinhibitor pathway[29,30 ] 。Piceatannol 廢除了ABCA1by 的刺激IL-10, 但沒有影響基礎線表示ofABCA1 。因而, ABCA1 的IL-10 刺激isproximally 被傳送通過經典IL-10 路, 而是IL-10 不是與基礎線ABCA1 expressionin 巨噬細胞相關。一個STAT 束縛的站點在ABCA1promoter 在350 bp ( 提供apotential 直接鏈接從IL 10 感受器官路toABCA1 表示。但這個約束主題不是STAT3specific, 也雀隻走H號從幾cytokinereceptors 。

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  • Anonymous
    1 decade ago


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  • Anonymous
    1 decade ago



    Source(s): College SCNC 100 Biology
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