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- 2 decades agoFavorite Answer
- YyLv 72 decades ago
奎寧 被認為懷孕時服用不引起畸胎 (原文紅色部分)有報導指出奎寧引起畸胎是因一次服用大量 且被用作墮胎劑 (原文藍色部分)母乳奎寧會隨乳汁分泌但一般認為無害Pregnancy There have been a large number of case reports of malformations following quinine ingestion in human pregnancy. Many of these pregnancies involved large doses of quinine used as an abortifacient. The most frequently reported abnormality following quinine exposure during early pregnancy is hypoplasia of the auditory nerve with resultant deafness. Other major malformations involving most organ systems have been reported also. However, the Perinatal Collaborative Study reported no association between first trimester exposure to quinine and birth defects. In general, there has been no proven association between quinine at doses used for malarial prophylaxis and an increased risk of malformations. Third trimester exposure to quinine does not appear to adversely effect uterine contractility. However, an increase in insulin secretion associated with hypoglycaemia has been reported. Therefore, monitoring of blood or serum glucose levels during quinine therapy is advisable. Breast milk Quinine is excreted into breast milk. Following 300 and 640 mg oral doses in six patients, milk concentrations varied up to 2.2 mcg/ml, with an average level of 1 mcg/ml at 3 hours. No adverse effects in breast fed babies were reported. Quinine is thought to be compatible with breast feeding (Bennet PN, 1988).
- Anonymous2 decades ago