During Solomons monologue in Ecclesiastes (1:17-18) there is an interesting statement:
Then I applied myself to the understanding of wisdom, and also of madness and folly, but I learned that this, too, is a chasing after the wind.
For with much wisdom comes much sorrow;
the more knowledge, the more grief.
He seems to have been in a negative mind set when he said it and I guess my lows are lower when I have more to be upset about so it seems true but knowledge often gives me a high as well.