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Withdrawal symptoms-
Anxiety, irritability, insomnia
Panic attacks, tremor
Seizures similar to delirium tremens (with long-term use of excessive doses)
100% of individuals treated on a long-term basis develop a form of dependence known as "low-dose dependence", as was shown in one double-blind, placebo-controlled study of 34 therapeutic low-dose benzodiazepine users—physiological dependence was demonstrated via flumazenil-precipitated withdrawal.[13] Use of alcohol or other CNS depressants while taking clonazepam greatly intensifies the effects (and side effects) of the drug. Side effects of the drug itself are generally benign, but sudden withdrawal after long-term use can cause severe, even fatal, symptoms.
Protracted withdrawal
10–15% of individuals treated with clonazepam on a long-term basis (in excess of 30 days of continuous use) develop a protracted withdrawal syndrome. Protracted withdrawal lasts for months, years, or a lifetime after clonazepam is discontinued. Protracted withdrawal results from structural brain damage, which is often irreversible.[14] Common protracted withdrawal symptoms include:[15]
Anxiety
Insomnia
Depression
Tinnitus
Tingling and numbness in limbs
Muscle pain and tension
Weakness
Cramps
Tremors
Irritable bowel
Cognitive dysfunction
Occasionally the withdrawalsymptoms last very long.
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