Yes, it says so on the side effects of the drug:
Adverse reactions reported by 1% to 5% of subjects using DEPO-PROVERA Contraceptive Injection were:
Decreased libido or anorgasmia
Pelvic pain
Backache
Breast pain
Leg cramps
No hair growth or alopecia
Depression
Bloating
Nausea
Rash
Insomnia
Edema
Leukorrhea
Hot flashes
Acne
Arthralgia
Vaginitis
Look at para 4:
The pretreatment physical examination should include special reference to breast and pelvic organs, as well as Papanicolaou smear.
Because progestogens may cause some degree of fluid retention, conditions which might be influenced by this factor, such as epilepsy, migraine, asthma, cardiac or renal dysfunction, require careful observation.
In cases of breakthrough bleeding, as in all cases of irregular bleeding per vaginum, nonfunctional causes should be borne in mind. In cases of undiagnosed vaginal bleeding, adequate diagnostic measures are indicated.
Patients who have a history of psychic depression should be carefully observed and the drug discontinued if the depression recurs to a serious degree.
Any possible influence of prolonged progestin therapy on pituitary, ovarian, adrenal, hepatic or uterine functions awaits further study.
Diabetic patients should be carefully observed while receiving progestin therapy.
The age of the patient constitutes no absolute limiting factor although treatment with progestins may mask the onset of the climacteric.
The pathologist should be advised of progestin therapy when relevant specimens are submitted.
Because of the occurrence of thrombotic disorders, (thrombophlebitis, pulmonary embolism, retinal thrombosis, and cerebrovascular disorders) in patients taking estrogen-progestin combinations and since the mechanism is obscure, the physician should be alert to the earliest manifestation of these disorders.
http://www.drugs.com/pro/medroxyprogeste…