My obvious answer would probably be a meeting of Superman and Batman, but there has been so much of that done, in the cartoons with Justice league and the Justice League unlimited, not to forget the Batman and Superman toons.
What truly struck me as wonderful was the new Fantastic Four cartoons. The guest appearances were amazing with the first volume of the first season featuring the Incredible Hulk and the Ant-man.
When I was watching those toons I got to thinking that it would be great to see Spider-man and the FF meet in the toons, but when I read your question, I would better like to see it on film.
It would be amazing stuff and throw in Dr. Doom, Green Goblin and to really shake the earth an appearance of Galactus and his herald Silver Surfer.
If this is masterfully done, comic book fans, the world over including myself would be besides ourselves.
Source(s):
My experience as a comic collector for more than 37 years.
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